{"id":"liberal-platelet-transfusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Alloimmunization"},{"rate":null,"effect":"Transfusion-related acute lung injury (TRALI)"},{"rate":null,"effect":"Febrile non-hemolytic transfusion reaction"},{"rate":null,"effect":"Bacterial contamination/sepsis"},{"rate":null,"effect":"Volume overload"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a transfusion strategy that administers platelets prophylactically or therapeutically to patients with low platelet counts (thrombocytopenia). The transfused platelets restore hemostatic function by increasing platelet numbers above critical thresholds, reducing spontaneous bleeding risk. The 'liberal' approach typically involves transfusing at higher platelet count thresholds compared to restrictive strategies.","oneSentence":"Liberal platelet transfusion increases circulating platelet counts to prevent or treat bleeding in thrombocytopenic patients.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:58.206Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thrombocytopenia in hematologic malignancies"},{"name":"Thrombocytopenia in patients undergoing chemotherapy"},{"name":"Prevention of bleeding in severely thrombocytopenic patients"}]},"trialDetails":[{"nctId":"NCT06676904","phase":"NA","title":"Neonatal Platelet Transfusion Threshold Trial","status":"RECRUITING","sponsor":"NICHD Neonatal Research Network","startDate":"2025-06-13","conditions":"Thrombocytopenia, Neonatal, Platelet Transfusion","enrollment":2433},{"nctId":"NCT04201704","phase":"NA","title":"Effect of Giving Reduced Fluid in Children After Trauma","status":"RECRUITING","sponsor":"Columbia University","startDate":"2018-08-27","conditions":"Critical Illness, Pediatrics, General Surgery","enrollment":250},{"nctId":"NCT05667805","phase":"PHASE4","title":"Coagulation in Cirrhosis","status":"RECRUITING","sponsor":"Medical University of Vienna","startDate":"2023-01-19","conditions":"Liver Cirrhosis","enrollment":400},{"nctId":"NCT03022253","phase":"PHASE3","title":"Platelet Transfusion for Treatment of Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2016-03","conditions":"Patent Ductus Arteriosus","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Liberal platelet transfusion","genericName":"Liberal platelet transfusion","companyName":"Post Graduate Institute of Medical Education and Research, Chandigarh","companyId":"post-graduate-institute-of-medical-education-and-research-chandigarh","modality":"Biologic","firstApprovalDate":"","aiSummary":"Liberal platelet transfusion increases circulating platelet counts to prevent or treat bleeding in thrombocytopenic patients. Used for Thrombocytopenia in hematologic malignancies, Thrombocytopenia in patients undergoing chemotherapy, Prevention of bleeding in severely thrombocytopenic patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}