{"id":"lgrastim-and-pegylated-filgrastim","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Bone pain"},{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Injection site reaction"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Filgrastim and pegylated filgrastim work by binding to and activating the granulocyte colony-stimulating factor receptor (G-CSFR), which triggers a signaling cascade that leads to the release of neutrophils from the bone marrow into the bloodstream. Pegylated filgrastim has a longer half-life than filgrastim due to the addition of polyethylene glycol (PEG) chains, allowing for less frequent dosing.","oneSentence":"Filgrastim and pegylated filgrastim stimulate the production of white blood cells, specifically neutrophils, to help the body fight infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:18:57.563Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduced febrile neutropenia in patients receiving myelosuppressive chemotherapy"},{"name":"Reduced infection risk in patients undergoing myeloablative chemotherapy or radiation"}]},"trialDetails":[{"nctId":"NCT01285219","phase":"PHASE3","title":"A Study Comparing Pegylated Filgrastim and Filgrastim in Support for Chemotherapy","status":"COMPLETED","sponsor":"Chinese Academy of Medical Sciences","startDate":"2006-01","conditions":"Cancer","enrollment":337}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":44,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"filgrastim and pegylated filgrastim","genericName":"filgrastim and pegylated filgrastim","companyName":"Chinese Academy of Medical Sciences","companyId":"chinese-academy-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Filgrastim and pegylated filgrastim stimulate the production of white blood cells, specifically neutrophils, to help the body fight infection. Used for Reduced febrile neutropenia in patients receiving myelosuppressive chemotherapy, Reduced infection risk in patients undergoing myeloablative chemotherapy or radiation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}