{"id":"levothyroxine-na-iodide","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Heat intolerance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levothyroxine sodium is a synthetic T4 (thyroxine) that is converted peripherally to the active T3 form, restoring thyroid hormone levels in hypothyroidism. The addition of iodide ensures adequate iodine availability for endogenous thyroid hormone production, addressing both hormone replacement and iodine deficiency simultaneously.","oneSentence":"Levothyroxine-Na replaces deficient thyroid hormone to restore normal metabolic function, while iodide provides substrate for thyroid hormone synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:06.759Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypothyroidism"},{"name":"Iodine deficiency with hypothyroidism"}]},"trialDetails":[{"nctId":"NCT00277589","phase":"PHASE4","title":"LISA-study : Levothyroxin in Nodular Goiter","status":"COMPLETED","sponsor":"Sanofi","startDate":"2004-05","conditions":"Goiter, Nodular","enrollment":1024}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Levothyroxine-Na + iodide","genericName":"Levothyroxine-Na + iodide","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levothyroxine-Na replaces deficient thyroid hormone to restore normal metabolic function, while iodide provides substrate for thyroid hormone synthesis. Used for Hypothyroidism, Iodine deficiency with hypothyroidism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}