{"id":"levosulpiride","rwe":[{"pmid":"41772689","year":"2026","title":"Central and Peripheral Neuromodulators in Functional Dyspepsia and Gastroparesis: A Symptom-Based Clinical Review.","finding":"","journal":"Neurogastroenterology and motility","studyType":"Clinical Study"},{"pmid":"41444452","year":"2026","title":"Similar short-term efficacy of oral levosulpiride and intravitreal ranibizumab in patients with diabetic macular oedema.","finding":"","journal":"Eye (London, England)","studyType":"Clinical Study"},{"pmid":"41100312","year":"2025","title":"Gastric Emptying Patterns in Type 2 Diabetes Mellitus Patients with Symptoms of Gastroparesis and the Impact of Levosulpiride on These Patterns.","finding":"","journal":"The Journal of the Association of Physicians of India","studyType":"Clinical Study"},{"pmid":"40878304","year":"2025","title":"Potentially Inappropriate Medication Use in Patients With Parkinson's Disease: Analysis of Korean National Health Insurance Claims Data.","finding":"","journal":"Journal of clinical neurology (Seoul, Korea)","studyType":"Clinical Study"},{"pmid":"40582526","year":"2025","title":"Development of novel electrospun nanofibers loaded with Levosulpiride and Cannabidiol encapsulated in cyclodextrin-phospholipid inclusion complex for ameliorated treatment of anxiety and depression.","finding":"","journal":"International journal of pharmaceutics","studyType":"Clinical Study"}],"tags":[{"label":"levosulpiride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(2) dopamine receptor","category":"target"},{"label":"DRD2","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"DRD4","category":"gene"},{"label":"N05AL07","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":106.997,"date":"","count":29,"signal":"Sopor","source":"DrugCentral FAERS","actionTaken":"Reported 29 times (LLR=107)"},{"llr":88.516,"date":"","count":18,"signal":"Cerebellar syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=89)"},{"llr":80.905,"date":"","count":16,"signal":"Galactorrhoea","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=81)"},{"llr":65.614,"date":"","count":12,"signal":"Disorganised speech","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=66)"},{"llr":61.57,"date":"","count":41,"signal":"Drug interaction","source":"DrugCentral FAERS","actionTaken":"Reported 41 times (LLR=62)"},{"llr":58.804,"date":"","count":20,"signal":"Serotonin syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 20 times (LLR=59)"},{"llr":55.328,"date":"","count":27,"signal":"Drug abuse","source":"DrugCentral FAERS","actionTaken":"Reported 27 times (LLR=55)"},{"llr":54.902,"date":"","count":12,"signal":"Hyperprolactinaemia","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=55)"}],"commonSideEffects":[{"effect":"Sopor","drugRate":"LLR 107","severity":"common"},{"effect":"Cerebellar syndrome","drugRate":"LLR 89","severity":"common"},{"effect":"Galactorrhoea","drugRate":"LLR 81","severity":"common"},{"effect":"Disorganised speech","drugRate":"LLR 66","severity":"common"},{"effect":"Drug interaction","drugRate":"LLR 62","severity":"common"},{"effect":"Serotonin syndrome","drugRate":"LLR 59","severity":"common"},{"effect":"Drug abuse","drugRate":"LLR 55","severity":"common"},{"effect":"Hyperprolactinaemia","drugRate":"LLR 55","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lesuride","offLabel":[],"synonyms":["levopraid","levosulpiride","(-)-Sulpiride","L-Sulpiride","lesuride","levobren","levopride"],"timeline":[],"aiSummary":"Lesuride, also known as Levosulpiride, is a small molecule drug that targets the D(2) dopamine receptor. It belongs to the levosulpiride class and is used to treat gastrointestinal disorders. However, its commercial status and approved indications are unclear. Further research is needed to determine its safety profile and potential side effects. As a result, it is not widely used in clinical practice.","approvals":[],"brandName":"Lesuride","ecosystem":[],"mechanism":{"target":"D(4) dopamine receptor, Myeloperoxidase, D(2) dopamine receptor","targets":[{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine receptor","protein":"D(4) dopamine receptor"},{"gene":"MPO","source":"DrugCentral","target":"Myeloperoxidase","protein":"Myeloperoxidase"}],"modality":"Small Molecule","drugClass":"levosulpiride","explanation":"Imagine your brain is like a switchboard, and dopamine is a messenger that helps control how your gut moves and digests food. Lesuride helps to fine-tune this process by blocking or activating certain dopamine receptors, which can help alleviate symptoms of gastrointestinal disorders.","oneSentence":"Lesuride works by binding to dopamine D(2) receptors in the brain, which helps to regulate gut motility and secretion.","technicalDetail":"Lesuride acts as a selective dopamine D(2) receptor antagonist, which leads to increased gastrointestinal motility and reduced gastric acid secretion, providing therapeutic benefits for patients with gastrointestinal disorders."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1577","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=LEVOSULPIRIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LEVOSULPIRIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:04:15.644984","biosimilars":[],"competitors":[{"drugName":"amisulpride","drugSlug":"amisulpride","fdaApproval":"2020-02-26","patentExpiry":"Mar 10, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"levosulpiride","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"amisulpride","brandName":"amisulpride","genericName":"amisulpride","approvalYear":"2020","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03161652","phase":"PHASE2","title":"Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema","status":"RECRUITING","sponsor":"Carmen Clapp","startDate":"2017-05-24","conditions":["Diabetic Macular Edema","Diabetic Retinopathy"],"enrollment":120,"completionDate":"2027-06"},{"nctId":"NCT04462211","phase":"NA","title":"Constipation Bundle/Protocol and the Effect of Adherence in the Incidence of Constipation in Critically Ill Patients","status":"COMPLETED","sponsor":"University of Chile","startDate":"2019-08-01","conditions":["Constipation","Critical Illness","Constipation Drug Induced"],"enrollment":66,"completionDate":"2020-03-01"},{"nctId":"NCT04697641","phase":"NA","title":"Helicobacter Pylori Eradication in Functional Dyspepsia","status":"COMPLETED","sponsor":"Sir Ganga Ram Hospital","startDate":"2017-09-01","conditions":["Dyspepsia","Helicobacter Pylori Infection"],"enrollment":202,"completionDate":"2019-05-31"},{"nctId":"NCT02481583","phase":"PHASE1","title":"Pharmacokinetic Study of Levosulpiride","status":"COMPLETED","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","startDate":"2013-03","conditions":["Dyspepsia"],"enrollment":42,"completionDate":"2013-05"},{"nctId":"NCT00866645","phase":"PHASE2,PHASE3","title":"A Study To Evaluate The Efficacy And Safety Of Intramuscular Levosulpiride In Patients With Agitation Of Schizophrenia","status":"COMPLETED","sponsor":"Shanghai Mental Health Center","startDate":"2009-02","conditions":["Agitation"],"enrollment":240,"completionDate":"2010-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"018683","UNII":"JTG7R315LK","CHEBI":"CHEBI:64119","INN_ID":"6593","UMLSCUI":"C0210380","ChEMBL_ID":"CHEMBL267044","KEGG_DRUG":"D07312","DRUGBANK_ID":"DB16021","PUBCHEM_CID":"688272","SNOMEDCT_US":"1179629009","IUPHAR_LIGAND_ID":"958","MESH_SUPPLEMENTAL_RECORD_UI":"C078143"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":159,"therapeuticAreas":["Gastroenterology"],"atcClassification":{"source":"DrugCentral","atcCode":"N05AL07","allCodes":["N05AL07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar","pmid":"41772689","title":"Central and Peripheral Neuromodulators in Functional Dyspepsia and Gastroparesis: A Symptom-Based Clinical Review.","journal":"Neurogastroenterology and motility"},{"date":"2026 Feb","pmid":"41444452","title":"Similar short-term efficacy of oral levosulpiride and intravitreal ranibizumab in patients with diabetic macular oedema.","journal":"Eye (London, England)"},{"date":"2025 Oct","pmid":"41100312","title":"Gastric Emptying Patterns in Type 2 Diabetes Mellitus Patients with Symptoms of Gastroparesis and the Impact of Levosulpiride on These Patterns.","journal":"The Journal of the Association of Physicians of India"},{"date":"2025 Sep","pmid":"40878304","title":"Potentially Inappropriate Medication Use in Patients With Parkinson's Disease: Analysis of Korean National Health Insurance Claims Data.","journal":"Journal of clinical neurology (Seoul, Korea)"},{"date":"2025 Sep 15","pmid":"40582526","title":"Development of novel electrospun nanofibers loaded with Levosulpiride and Cannabidiol encapsulated in cyclodextrin-phospholipid inclusion complex for ameliorated treatment of anxiety and depression.","journal":"International journal of pharmaceutics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}