{"id":"levosimontane-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levosimontane works by binding to cardiac troponin C, enhancing the sensitivity of contractile proteins to calcium and thereby improving myocardial contractility. Additionally, it opens ATP-sensitive potassium channels in vascular smooth muscle, producing vasodilation of both arteries and veins. This dual mechanism makes it useful in acute decompensated heart failure by improving cardiac output while reducing cardiac workload and improving hemodynamics.","oneSentence":"Levosimontane is a calcium sensitizer that increases the force of cardiac muscle contraction without increasing oxygen consumption, while also causing vasodilation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:06.945Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute decompensated heart failure"},{"name":"Cardiogenic shock"}]},"trialDetails":[{"nctId":"NCT06196177","phase":"PHASE4","title":"Effects of Levosimendan on Cardiac Function After TAVR in Patients With Heart Failure","status":"UNKNOWN","sponsor":"Qilu Hospital of Shandong University","startDate":"2024-03-01","conditions":"Heart Failure, Aortic Stenosis, Severe","enrollment":112}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["wen，yue"],"phase":"marketed","status":"active","brandName":"Levosimontane injection","genericName":"Levosimontane injection","companyName":"Qilu Hospital of Shandong University","companyId":"qilu-hospital-of-shandong-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levosimontane is a calcium sensitizer that increases the force of cardiac muscle contraction without increasing oxygen consumption, while also causing vasodilation. Used for Acute decompensated heart failure, Cardiogenic shock.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}