{"id":"levornidazole-disodium-phosphate-for-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Metallic taste"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Peripheral neuropathy (with prolonged use)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL170812","moleculeType":"Small molecule","molecularWeight":"401.35"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As the active L-enantiomer of ornidazole, levornidazole penetrates microbial cells and is reduced by anaerobic metabolism to form reactive intermediates that bind to DNA, causing strand breaks and cell death. It is effective against anaerobic bacteria and certain protozoan parasites, particularly Entamoeba histolytica and Trichomonas vaginalis. The disodium phosphate salt formulation enables intravenous administration for systemic infections.","oneSentence":"Levornidazole is a nitroimidazole antimicrobial that generates reactive oxygen species to damage DNA and disrupt cellular function in anaerobic microorganisms and certain parasites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:33:56.780Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anaerobic bacterial infections"},{"name":"Amebic dysentery and extraintestinal amebiasis"},{"name":"Trichomoniasis"},{"name":"Other protozoal and anaerobic infections"}]},"trialDetails":[{"nctId":"NCT07033182","phase":"PHASE1","title":"Pharmacokinetics and Safety Study of Levornidazole Disodium Phosphate for Injection in Subjects With Renal Impairment and Normal Renal Impairment","status":"COMPLETED","sponsor":"Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd","startDate":"2023-10-30","conditions":"Infections Caused by Anaerobic Bacteria, Renal Impairment","enrollment":24},{"nctId":"NCT06828874","phase":"PHASE4","title":"A Study of Levornidazole Disodium Phosphate for Injection vs. Ornidazole in Treatment of Postoperative Intra-Abdominal Infections Caused by Anaerobic Bacteria","status":"COMPLETED","sponsor":"Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd","startDate":"2023-05-10","conditions":"Intraabdominal Infections","enrollment":696}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Levornidazole Disodium Phosphate for Injection","genericName":"Levornidazole Disodium Phosphate for Injection","companyName":"Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd","companyId":"yangtze-river-pharmaceutical-group-jiangsu-zilong-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levornidazole is a nitroimidazole antibiotic that generates reactive oxygen species and damages microbial DNA, killing anaerobic bacteria and certain parasites. Used for Anaerobic bacterial infections, Trichomoniasis, Amebic dysentery and liver abscess.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}