{"id":"levonorgestrel-bay98-7196","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Irregular bleeding"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1389","moleculeType":"Small molecule","molecularWeight":"312.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levonorgestrel acts as a progestin receptor agonist, primarily inhibiting the luteinizing hormone (LH) surge necessary for ovulation. It also increases cervical mucus viscosity to impede sperm transport and alters the endometrium to reduce implantation likelihood. As a second-generation progestin, it has been widely used in oral contraceptives and emergency contraception for decades.","oneSentence":"Levonorgestrel is a synthetic progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:18:50.197Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral contraception"},{"name":"Emergency contraception"}]},"trialDetails":[{"nctId":"NCT02203331","phase":"PHASE2","title":"Bay98-7196, Dose Finding / POC Study","status":"COMPLETED","sponsor":"Bayer","startDate":"2014-10-16","conditions":"Endometriosis","enrollment":319},{"nctId":"NCT02403401","phase":"PHASE3","title":"Safety and Contraceptive Efficacy of an Intravaginal Ring With LNG (Levonorgestrel) Over One Year in Healthy Women","status":"COMPLETED","sponsor":"Bayer","startDate":"2015-05-15","conditions":"Contraception","enrollment":1471},{"nctId":"NCT02545452","phase":"PHASE1","title":"Effect of Concomitant Use of an Antimycotic, an Antibiotic, a Spermicide or Tampons on Pharmacokinetics of Anastrozole and Levonorgestrel Released From Intra-vaginal Ring","status":"COMPLETED","sponsor":"Bayer","startDate":"2015-09-15","conditions":"Endometriosis","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Levonorgestrel (BAY98-7196)","genericName":"Levonorgestrel (BAY98-7196)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levonorgestrel is a synthetic progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions. Used for Oral contraception, Emergency contraception.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}