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In sequential therapy protocols, levofloxacin is administered in a defined sequence with other antimicrobial agents (typically proton pump inhibitors and other antibiotics) to improve eradication rates of H. pylori and reduce antibiotic resistance compared to standard triple or dual therapy.","oneSentence":"Levofloxacin-based sequential therapy uses a fluoroquinolone antibiotic in a multi-step treatment regimen to eradicate bacterial infections, particularly Helicobacter pylori in peptic ulcer disease.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:59.767Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Helicobacter pylori eradication in peptic ulcer disease (as part of sequential therapy regimen)"}]},"trialDetails":[{"nctId":"NCT04332848","phase":"PHASE4","title":"Susceptibility Testing Guided Versus Empirical Therapy for Refractory H. 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Pylori Infection With Moxifloxacin","status":"COMPLETED","sponsor":"Iyad Naeem Muhammad, PhD","startDate":"2020-06-01","conditions":"Helicobacter Pylori Infection, Helicobacter Pylori Infection, Susceptibility to","enrollment":162},{"nctId":"NCT03148366","phase":"PHASE3","title":"Comparison of the Levofloxacin Sequential Therapy and Quadruple Therapy in Second Line Treatment for HP","status":"COMPLETED","sponsor":"National Taiwan University Hospital","startDate":"2015-02","conditions":"Helicobacter","enrollment":560},{"nctId":"NCT03556254","phase":"PHASE4","title":"Genotypic Resistance Guided Versus Susceptibility Testing Guided Therapy for the First-line Eradication of H. Pylori","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2018-03-29","conditions":"Helicobacter Pylori Infection","enrollment":560},{"nctId":"NCT02466919","phase":"PHASE4","title":"Study of Levofloxacin-based Concomitant Therapy for H. 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Pylori Infection","enrollment":142}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Takepron","Cravit","Flagyl","Amoxicillin"],"phase":"marketed","status":"active","brandName":"levofloxacin-based sequential therapy","genericName":"levofloxacin-based sequential therapy","companyName":"National Taiwan University Hospital","companyId":"national-taiwan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levofloxacin-based sequential therapy uses a fluoroquinolone antibiotic in a multi-step treatment regimen to eradicate bacterial infections, particularly Helicobacter pylori in peptic ulcer disease. Used for Helicobacter pylori eradication in peptic ulcer disease (as part of sequential therapy regimen).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}