{"id":"levodropropizine","rwe":[],"tags":[{"label":"levodropropizine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05DB27","category":"atc"},{"label":"Active","category":"status"},{"label":"Antitussive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"phase_3","safety":{"commonSideEffects":[{"effect":"Headache","drugRate":"5.4%","placeboRate":"","totalAtRisk":92,"totalAffected":5,"trialsReporting":1},{"effect":"Dry mouth","drugRate":"2.2%","placeboRate":"","totalAtRisk":92,"totalAffected":2,"trialsReporting":1},{"effect":"Alanine aminotransferase increased","drugRate":"2.2%","placeboRate":"","totalAtRisk":92,"totalAffected":2,"trialsReporting":1},{"effect":"Hypoaesthesia oral","drugRate":"1.1%","placeboRate":"","totalAtRisk":92,"totalAffected":1,"trialsReporting":1},{"effect":"Nausea","drugRate":"1.1%","placeboRate":"","totalAtRisk":92,"totalAffected":1,"trialsReporting":1},{"effect":"Dizziness","drugRate":"1.1%","placeboRate":"","totalAtRisk":92,"totalAffected":1,"trialsReporting":1},{"effect":"Malaise","drugRate":"1.1%","placeboRate":"","totalAtRisk":92,"totalAffected":1,"trialsReporting":1},{"effect":"Aspartate aminitransferase increased","drugRate":"1.1%","placeboRate":"","totalAtRisk":92,"totalAffected":1,"trialsReporting":1},{"effect":"Haematuria","drugRate":"1.1%","placeboRate":"","totalAtRisk":92,"totalAffected":1,"trialsReporting":1},{"effect":"Gastroduodenitis","drugRate":"0.0%","placeboRate":"","totalAtRisk":92,"totalAffected":0,"trialsReporting":1},{"effect":"Abdominal pain","drugRate":"0.0%","placeboRate":"","totalAtRisk":92,"totalAffected":0,"trialsReporting":1},{"effect":"Dysgeusia","drugRate":"0.0%","placeboRate":"","totalAtRisk":92,"totalAffected":0,"trialsReporting":1},{"effect":"Sleep disorders","drugRate":"0.0%","placeboRate":"","totalAtRisk":92,"totalAffected":0,"trialsReporting":1}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"(-)-dropropizine","offLabel":[],"synonyms":["levodropropizine","(-)-Dropropizine"],"timeline":[],"approvals":[],"brandName":"(-)-Dropropizine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"levodropropizine","explanation":"Imagine your nervous system as a complex network of messengers that help your body respond to different stimuli. Levodropropizine is believed to affect the way these messengers work, which can help alleviate symptoms of certain respiratory conditions. However, the exact details of how it achieves this are still not fully understood.","oneSentence":"Levodropropizine is thought to work by modulating the activity of certain neurotransmitters in the nervous system.","technicalDetail":"Levodropropizine is a small molecule that interacts with specific receptors and enzymes in the nervous system, potentially influencing the release and activity of neurotransmitters such as acetylcholine and dopamine."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1568","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=LEVODROPROPIZINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LEVODROPROPIZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:19:15.126183","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:44:13.313737+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"benzonatate","drugSlug":"benzonatate","fdaApproval":"1958-02-10","genericCount":13,"patentStatus":"Off-patent — generic 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Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis","status":"WITHDRAWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2011-08","conditions":["Nasal Congestion","Cough"],"enrollment":0,"completionDate":"2013-01"},{"nctId":"NCT01177852","phase":"PHASE3","title":"Evaluation of Efficacy and Safety in Control Cough and the Relief of Nasal Symptoms in Children 2-12 Years Old,Suffering From Cough and Acute Rhinitis","status":"WITHDRAWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2011-10","conditions":["Inflammation","Cough","Rhinitis"],"enrollment":0,"completionDate":""},{"nctId":"NCT01573663","phase":"PHASE1","title":"A Drug-Drug Interaction Study of Ambroxol and Levodropropizine","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company 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