{"id":"levocetirizine-plus-hydroxyzine","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL3186993","moleculeType":"Small molecule","molecularWeight":"447.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levocetirizine is a selective H1-receptor antagonist that crosses the blood-brain barrier minimally, reducing histamine-mediated allergic responses. Hydroxyzine is a first-generation antihistamine with additional anxiolytic and anticholinergic properties. Together, they provide complementary antihistamine coverage for allergic conditions.","oneSentence":"This combination blocks histamine H1 receptors to reduce allergic symptoms and itching.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:52.414Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Urticaria"},{"name":"Pruritus and allergic dermatitis"}]},"trialDetails":[{"nctId":"NCT01250652","phase":"PHASE4","title":"Levocetirizine Plus Bed-Time Hydroxyzine in the Management of Corticodependent Chronic Urticaria Versus Levocetirizine Alone in High Doses","status":"COMPLETED","sponsor":"Association Asthma, Bulgaria","startDate":"2011-03","conditions":"Chronic Urticaria","enrollment":24},{"nctId":"NCT00375713","phase":"PHASE3","title":"Randomized Phase III Study to Evaluate the Efficacy and Safety of Xyzal® (Levocetirizine) vs Zyrtec® (Cetirizine) in Subjects With Dermatitis and Eczema","status":"COMPLETED","sponsor":"UCB Pharma","startDate":"2005-10","conditions":"Dermatitis, Eczema","enrollment":466}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xyzal plus Atarax"],"phase":"marketed","status":"active","brandName":"Levocetirizine plus Hydroxyzine","genericName":"Levocetirizine plus Hydroxyzine","companyName":"Association Asthma, Bulgaria","companyId":"association-asthma-bulgaria","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination blocks histamine H1 receptors to reduce allergic symptoms and itching. Used for Allergic rhinitis, Urticaria, Pruritus and allergic dermatitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}