{"id":"levocept","safety":{"commonSideEffects":[{"rate":null,"effect":"Hot flashes"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Muscle pain"},{"rate":null,"effect":"Leg cramps"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"LevoCept acts as a tissue-selective estrogen receptor modulator, binding to estrogen receptors with differential activity across tissues. This allows it to provide estrogen-like benefits in some tissues (such as bone and vasomotor symptom relief) while avoiding unwanted estrogenic effects in others (such as breast and endometrium), making it suitable for menopausal hormone therapy.","oneSentence":"LevoCept is a selective estrogen receptor modulator (SERM) that modulates estrogen signaling to treat menopausal symptoms and related conditions in women.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:26.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vasomotor symptoms associated with menopause"},{"name":"Menopausal bone health and osteoporosis prevention"}]},"trialDetails":[{"nctId":"NCT04457076","phase":"PHASE3","title":"Evaluation of the Efficacy, Safety, and Tolerability of LevoCept","status":"NOT_YET_RECRUITING","sponsor":"Sebela Women's Health Inc.","startDate":"2026-06-01","conditions":"Contraception, Women at Risk for Pregnancy","enrollment":1525},{"nctId":"NCT02882191","phase":"PHASE2","title":"Evaluation of the Efficacy and Safety of LevoCept","status":"COMPLETED","sponsor":"Sebela Women's Health Inc.","startDate":"2016-11","conditions":"Contraception","enrollment":279}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Levonorgestrel-Releasing Intrauterine System"],"phase":"phase_3","status":"active","brandName":"LevoCept","genericName":"LevoCept","companyName":"Sebela Women's Health Inc.","companyId":"sebela-women-s-health-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LevoCept is a selective estrogen receptor modulator (SERM) that modulates estrogen signaling to treat menopausal symptoms and related conditions in women. Used for Vasomotor symptoms associated with menopause, Menopausal bone health and osteoporosis prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}