{"id":"levocabastine-hcl","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Taste perversion"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levocabastine competitively binds to H1 histamine receptors on mast cells and other immune cells, preventing histamine release and reducing allergic symptoms such as itching, sneezing, and nasal congestion. It is a non-sedating antihistamine formulated for intranasal or ophthalmic delivery to provide rapid local relief of allergic rhinitis and allergic conjunctivitis.","oneSentence":"Levocabastine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:53.035Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Allergic conjunctivitis"}]},"trialDetails":[{"nctId":"NCT04002349","phase":"NA","title":"Study of Medication for Nonallergic Rhinitis (NAR) Based on Cluster Analysis","status":"UNKNOWN","sponsor":"Beijing Tongren Hospital","startDate":"2019-07-01","conditions":"Determination of the Efficacy of Different Medications for Idiopathic Rhinitis, Impact of Different Medications on Biomarkers of Idiopathic Rhinitis, Safety and Tolerance of Different Medications for Idiopathic Rhinitis","enrollment":80},{"nctId":"NCT01949051","phase":"PHASE2","title":"A Study to Assess Intranasal Repeat Dose Effect of Levocabastine in the Subjects With Allergic Rhinitis","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-10-01","conditions":"Rhinitis, Allergic, Perennial and Seasonal","enrollment":78},{"nctId":"NCT01962467","phase":"PHASE1","title":"A Relative Bioavailability Study of Fluticasone Furoate and Levocabastine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-10-11","conditions":"Rhinitis, Allergic, Perennial and Seasonal","enrollment":30},{"nctId":"NCT01957202","phase":"PHASE2","title":"A Proof of Concept Study to Assess Effect of Fluticasone Furoate (FF)/Levocabastine Fixed Dose Combination (FDC) Compared With Levocabastine and FF Alone in Subjects With Allergic Rhinitis (AR)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-10","conditions":"Rhinitis, Allergic, Perennial and Seasonal","enrollment":71},{"nctId":"NCT02498509","phase":"PHASE3","title":"Clinical Trial to Evaluate the Efficacy and Safety of CKD-342","status":"COMPLETED","sponsor":"Chong Kun Dang Pharmaceutical","startDate":"2015-05","conditions":"Rhinitis, Allergic, Perennial","enrollment":459}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"INTERNATIONAL NORMALISED RATIO INCREASED"},{"count":1,"reaction":"ARTHRALGIA"},{"count":1,"reaction":"CHEST PAIN"},{"count":1,"reaction":"COUGH"},{"count":1,"reaction":"DRUG EXPOSURE DURING PREGNANCY"},{"count":1,"reaction":"DRUG INTERACTION"},{"count":1,"reaction":"DRY MOUTH"},{"count":1,"reaction":"DYSPNOEA"},{"count":1,"reaction":"HALLUCINATION"},{"count":1,"reaction":"HYPOGLYCAEMIA"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["investigational product"],"phase":"phase_3","status":"active","brandName":"Levocabastine HCL","genericName":"Levocabastine HCL","companyName":"Chong Kun Dang Pharmaceutical","companyId":"chong-kun-dang-pharmaceutical","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levocabastine HCL is a medication used to treat perennial and seasonal allergic rhinitis. It is studied in clinical trials alongside other medications, such as CKD-342 and Mometasone furoate, to evaluate its efficacy and safety.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}