{"id":"levobupivacaine-wound-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation"},{"rate":null,"effect":"Systemic toxicity (if absorbed in high concentrations)"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. When infused into wound tissue, it penetrates nerve cell membranes and reversibly blocks voltage-gated sodium channels, preventing depolarization and propagation of action potentials. This results in local anesthesia and analgesia at the surgical wound site, reducing postoperative pain.","oneSentence":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission at the wound site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:53.043Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative wound pain management via local infiltration"}]},"trialDetails":[{"nctId":"NCT04665531","phase":"NA","title":"Postoperative Analgesia With a Catheter Under the Erector Spinae Muscle for Videothoracoscopic Lung Surgery","status":"COMPLETED","sponsor":"Surgery Bitenc","startDate":"2020-02-19","conditions":"Neoplasm of Lung, Thoracic Surgery, Video-Assisted","enrollment":50},{"nctId":"NCT05409144","phase":"NA","title":"Impact of Thoracic Epidural Versus Serratus Anterior Plane Block Versus Erector Spinae Plane Block on Incidence of PTPS","status":"UNKNOWN","sponsor":"National Cancer Institute, Egypt","startDate":"2022-06-20","conditions":"Post-thoracotomy Pain Syndrome, Erector Spinae Plane Block, Serratus Anterior Plane Block","enrollment":111},{"nctId":"NCT02728310","phase":"PHASE3","title":"Local Continuous Wound Infusion of Anesthetics in the Management of Post-operative Pain After Total Hip Arthroplasty.","status":"TERMINATED","sponsor":"San Salvatore Hospital of L'Aquila","startDate":"2012-09","conditions":"Pain","enrollment":96},{"nctId":"NCT02035904","phase":"PHASE4","title":"Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery","status":"UNKNOWN","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2013-01","conditions":"Acute Pain, Chronic Pain, Wound Infusion","enrollment":60},{"nctId":"NCT01916915","phase":"PHASE4","title":"Usage of Tramadol With Levobupivacaine for Pain Treatment After Cesarean Section","status":"COMPLETED","sponsor":"Ufuk University","startDate":"2013-07","conditions":"Pain, Postoperative","enrollment":65},{"nctId":"NCT02677532","phase":"PHASE4","title":"Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair","status":"COMPLETED","sponsor":"University of Genova","startDate":"2011-12","conditions":"Postoperative Pain","enrollment":51},{"nctId":"NCT02478372","phase":"NA","title":"Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty","status":"COMPLETED","sponsor":"Golden Jubilee National Hospital","startDate":"2010-04","conditions":"Osteoarthritis","enrollment":242},{"nctId":"NCT01458431","phase":"PHASE3","title":"Levobupivacaine to the Surgical Wound Following Cesarean","status":"COMPLETED","sponsor":"Manuel Ángel Gómez-Ríos","startDate":"2011-10","conditions":"Postoperative Pain","enrollment":70},{"nctId":"NCT01312077","phase":"PHASE4","title":"The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement","status":"UNKNOWN","sponsor":"Cork University Hospital","startDate":"2010-10","conditions":"Total Hip Arthroplasty","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Levobupivacaine wound infusion","genericName":"Levobupivacaine wound infusion","companyName":"University of Genova","companyId":"university-of-genova","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission at the wound site. Used for Postoperative wound pain management via local infiltration.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}