{"id":"levobupivacaine-0-1-sufentanil-0-2-g-ml","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Urinary retention"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is a long-acting local anesthetic that inhibits sodium influx in nerve fibers, preventing action potential propagation and sensory/motor blockade in a localized region. Sufentanil is a potent synthetic opioid agonist at mu opioid receptors that enhances analgesia. This combination is used for epidural or regional anesthesia to provide both sensory blockade and opioid-mediated pain relief.","oneSentence":"Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil activates opioid receptors to provide analgesia, together delivering regional anesthesia and pain relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:47.279Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia and analgesia (epidural administration)"},{"name":"Perioperative pain management"}]},"trialDetails":[{"nctId":"NCT02264834","phase":"PHASE3","title":"Deambulatory Epidural During the Labour","status":"COMPLETED","sponsor":"Dr Madeleine Wilwerth","startDate":"2014-07-01","conditions":"First Pregnancy","enrollment":164}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["control group"],"phase":"phase_3","status":"active","brandName":"Levobupivacaine 0.1% + Sufentanil 0.2µg/ml","genericName":"Levobupivacaine 0.1% + Sufentanil 0.2µg/ml","companyName":"Dr Madeleine Wilwerth","companyId":"dr-madeleine-wilwerth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil activates opioid receptors to provide analgesia, together delivering regional anesthesia and pain relief. Used for Regional anesthesia and analgesia (epidural administration), Perioperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}