{"id":"levobupivacaine-0-07-sufentanil-0-3-g-ml","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is a long-acting local anesthetic that inhibits sodium influx in nerve fibers, preventing action potential propagation and sensory/motor blockade in a localized region. Sufentanil is a potent synthetic opioid agonist at mu opioid receptors that enhances analgesia and reduces pain perception. This combination is used for epidural or regional anesthesia to provide both sensory blockade and opioid-mediated analgesia.","oneSentence":"Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil activates opioid receptors to provide analgesia, together delivering regional anesthesia and pain relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:42.886Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia and analgesia for epidural administration"},{"name":"Postoperative pain management via epidural infusion"}]},"trialDetails":[{"nctId":"NCT02264834","phase":"PHASE3","title":"Deambulatory Epidural During the Labour","status":"COMPLETED","sponsor":"Dr Madeleine Wilwerth","startDate":"2014-07-01","conditions":"First Pregnancy","enrollment":164}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ambulatory group"],"phase":"phase_3","status":"active","brandName":"Levobupivacaine 0.07% + Sufentanil 0.3µg/ml","genericName":"Levobupivacaine 0.07% + Sufentanil 0.3µg/ml","companyName":"Dr Madeleine Wilwerth","companyId":"dr-madeleine-wilwerth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil activates opioid receptors to provide analgesia, together delivering regional anesthesia and pain relief. Used for Regional anesthesia and analgesia for epidural administration, Postoperative pain management via epidural infusion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}