{"id":"levobetaxolol-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or discomfort"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Systemic beta-blocker effects (rare with topical formulation)"}]},"_chembl":{"chemblId":"CHEMBL1200837","moleculeType":"Small molecule","molecularWeight":"343.90"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a beta-blocker, levobetaxolol selectively inhibits beta-1 adrenergic receptors in the ciliary body of the eye, which reduces the production and secretion of aqueous humor. This decrease in aqueous humor production leads to lower intraocular pressure, making it effective for treating glaucoma and ocular hypertension. The selective beta-1 activity minimizes systemic side effects compared to non-selective beta-blockers.","oneSentence":"Levobetaxolol is a selective beta-1 adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:43.064Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT02617459","phase":"PHASE3","title":"Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.","startDate":"2019-01-04","conditions":"Primary Open-angle Glaucoma, Ocular Hypertension","enrollment":366}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Levobetaxolol eye drops","genericName":"Levobetaxolol eye drops","companyName":"Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.","companyId":"zhaoke-guangzhou-ophthalmology-pharmaceutical-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobetaxolol is a selective beta-1 adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye. Used for Glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}