{"id":"levmetamfetamine","rwe":[],"_fda":{"id":"2fd33bbc-1aa7-4742-8bed-f986aeae6494","set_id":"3f1c086c-bc22-4abb-9921-565a13f30c20","openfda":{"upc":["0070038650171"],"unii":["Y24T9BT2Q2"],"route":["NASAL"],"spl_id":["2fd33bbc-1aa7-4742-8bed-f986aeae6494"],"brand_name":["Vapor Inhaler levmetamfetamine nasal decongestant, Best Choice"],"spl_set_id":["3f1c086c-bc22-4abb-9921-565a13f30c20"],"package_ndc":["63941-981-07"],"product_ndc":["63941-981"],"generic_name":["LEVMETAMFETAMINE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["LEVMETAMFETAMINE"],"manufacturer_name":["Valu Merchandisers Company"],"application_number":["M012"],"is_original_packager":[true]},"purpose":["Purpose Nasal decongestant"],"version":"3","stop_use":["Stop use and ask a doctor if symptoms persist"],"warnings":["Warnings When using this product do not exceed recommended dosage temporary burning, stinging, sneezing, or increased nasal Squareharge may occur use of this container by more than one person may spread infection do not use for more than 7 days • use only as directed frequent or prolonged use may cause nasal congestion to recur or worsen Stop use and ask a doctor if symptoms persist If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"questions":["Questions or comments? 1-888-586-7979"],"do_not_use":["do not use for more than 7 days • use only as directed frequent or prolonged use may cause nasal congestion to recur or worsen Stop use and ask a doctor if symptoms persist If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"when_using":["When using this product do not exceed recommended dosage temporary burning, stinging, sneezing, or increased nasal Squareharge may occur use of this container by more than one person may spread infection"],"effective_time":"20241220","active_ingredient":["Active ingredient (per inhaler) Levmetamfetamine 50 mg"],"inactive_ingredient":["Inactive ingredients bornyl acetate, camphor, lavender oil, menthol, methyl salicylate"],"indications_and_usage":["Use: for temporary relief of nasal congestion due to: the common cold hay fever or upper respiratory allergies"],"other_safety_information":["Other information this inhaler is effective for a minimum of 3 months after first use keep inhaler tightly closed store at 59°-86° F (15°-30° C)"],"dosage_and_administration":["Directions the product delivers in each 800 mL of air 0.04 to 0.150 mg of levmetamfetamine do not use more often than every 2 hours adults and children 12 years of age and over 2 inhalations in each nostril children 6 to under 12 years of age (with adult supervision) 1 inhalation in each nostril children under 6 years of age ask a doctor children under 2 years of age do not use"],"spl_product_data_elements":["Vapor Inhaler levmetamfetamine nasal decongestant, Best Choice Levmetamfetamine Levmetamfetamine Levmetamfetamine Bornyl acetate Camphor (Synthetic) Lavender oil Menthol Methyl Salicylate"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use."],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"dosage_and_administration_table":["<table width=\"100%\"><col width=\"68.250%\" align=\"left\"/><col width=\"31.750%\" align=\"left\"/><tbody><tr><td align=\"left\" valign=\"bottom\" styleCode=\"Toprule Botrule Rrule\">adults and children 12 years of age and over </td><td align=\"left\" valign=\"bottom\" styleCode=\"Toprule Botrule\">2 inhalations in each nostril </td></tr><tr><td align=\"left\" valign=\"bottom\" styleCode=\"Botrule Rrule\">children 6 to under 12 years of age (with adult supervision) </td><td align=\"left\" valign=\"top\" styleCode=\"Botrule\">1 inhalation in each nostril </td></tr><tr><td align=\"left\" valign=\"bottom\" styleCode=\"Botrule Rrule\">children under 6 years of age </td><td align=\"left\" valign=\"bottom\" styleCode=\"Botrule\">ask a doctor </td></tr><tr><td align=\"left\" valign=\"top\" styleCode=\"Rrule\">children under 2 years of age </td><td align=\"left\" valign=\"top\">do not use </td></tr></tbody></table>"],"package_label_principal_display_panel":["Principal Display Panel - 15 mg Blister Pack Label NDC 63941-981-07 Best Choice® COMPARE TO THE ACTIVE INGREDIENT OF VICKS® VAPOINHALER®* Nasal Decongestant Vapor Inhaler Levmetamfetamine Nasal Decongestant Temporary Relief of Nasal Congestion due to: Colds Hay Fever Upper Respiratory Allergies NET WT .007 oz (198 mg) Principal Display Panel - 15 mg Blister Pack Label","Principal Display Panel - 15 mg Inhaler Label NDC 63941-981-07 Best Choice® Nasal Decongestant Vapor Inhaler Levmetamfetamine Nasal Decongestant NET WT .007oz (198 mg) Principal Display Panel - 15 mg Inhaler Label"]},"tags":[{"label":"levmetamfetamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Trace amine-associated receptor 1","category":"target"},{"label":"TAAR1","category":"gene"},{"label":"Nasal","category":"route"},{"label":"Inhalant","category":"form"},{"label":"Active","category":"status"},{"label":"Nasal congestion","category":"indication"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"ACNE","source":"FDA FAERS","actionTaken":"1 reports"},{"date":"","signal":"ACUTE KIDNEY INJURY","source":"FDA FAERS","actionTaken":"1 reports"},{"date":"","signal":"BLOOD GASES ABNORMAL","source":"FDA FAERS","actionTaken":"1 reports"},{"date":"","signal":"CHRONIC OBSTRUCTIVE PULMONARY DISEASE","source":"FDA FAERS","actionTaken":"1 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"1 reports"},{"date":"","signal":"FALL","source":"FDA FAERS","actionTaken":"1 reports"},{"date":"","signal":"INFECTION","source":"FDA FAERS","actionTaken":"1 reports"},{"date":"","signal":"INTERVERTEBRAL DISC PROTRUSION","source":"FDA FAERS","actionTaken":"1 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congestion","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null}],"mechanism":{"target":"Trace amine-associated receptor 1","novelty":"First-in-class","targets":[{"gene":"TAAR1","source":"DrugCentral","target":"Trace amine-associated receptor 1","protein":"Trace amine-associated receptor 1"}],"modality":"Small Molecule","drugClass":"levmetamfetamine","explanation":"","oneSentence":"","technicalDetail":"Levomethamphetamine acts as a selective agonist of the trace amine-associated receptor 1 (TAAR1), which is involved in the regulation of nasal mucosal blood flow and swelling."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Levomethamphetamine","title":"Levomethamphetamine","extract":"Levomethamphetamine is an optical isomer of methamphetamine primarily used as a topical nasal decongestant. Levomethamphetamine is used to treat nasal congestion from allergies and the common cold. It was first used medically as decongestant beginning in 1958 and has been used for such purposes, primarily in the United States, since then.","wiki_history":"==History==\nMethamphetamine, a racemic mixture of dextromethamphetamine and levomethamphetamine, was first discovered and synthesized in 1919. Methamphetamine was first introduced for medical use in 1938 in oral form under the brand name Pervitin in Germany. By 1995, the brand name was changed to Vicks Vapor Inhaler. In 1998, the United States Food and Drug Administration (FDA) required that the chemical name on the labeling be changed from l-desoxyephedrine to levmetamfetamine.","wiki_society_and_culture":"==Society and culture==\n===Legal status===\nLevomethamphetamine is a controlled substance in the Philippines.\n\n===Recreational use===\nAs of 2006, there were no studies demonstrating \"drug liking\" scores of oral levomethamphetamine that are similar to racemic methamphetamine or dextromethamphetamine in either recreational users or medicinal users.\n\nIn 2012, tighter controls in Mexico on certain methamphetamine precursors like ephedrine and pseudoephedrine led to a greater percentage of illicit methamphetamine from Mexican drug cartels consisting of a higher ratio of levomethamphetamine to dextromethamphetamine within batches of racemic methamphetamine."},"commercial":{"revenueYear":2025,"annualRevenue":172,"revenueSource":"Teva 2026-02-03 (verified from SEC 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