{"id":"levetiracetam-clonazepam","safety":{"commonSideEffects":[{"rate":null,"effect":"Somnolence / Sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Ataxia / Coordination impairment"},{"rate":null,"effect":"Cognitive impairment"},{"rate":null,"effect":"Dependence / Withdrawal risk (clonazepam component)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levetiracetam binds to synaptic vesicle protein 2A (SV2A) and reduces calcium influx at presynaptic terminals, thereby decreasing neurotransmitter release and neuronal hyperexcitability. Clonazepam potentiates GABA-A receptor signaling, increasing chloride influx and hyperpolarizing neurons. Together, they provide dual anticonvulsant mechanisms targeting both synaptic modulation and GABAergic inhibition.","oneSentence":"This combination drug pairs levetiracetam, which modulates synaptic vesicle proteins to reduce neuronal excitability, with clonazepam, a benzodiazepine that enhances GABAergic inhibition in the central nervous system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:51.651Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure disorders / Epilepsy (combination therapy)"},{"name":"Status epilepticus (acute seizure management)"}]},"trialDetails":[{"nctId":"NCT01150331","phase":"PHASE3","title":"Study of Antiepileptic Drug in Generalised Convulsive Status Epilepticus","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2009-07","conditions":"Status; Epilepticus, Tonic-clonic","enrollment":203},{"nctId":"NCT05737511","phase":"PHASE4","title":"Efficacy of Hydroxyzine for Patients With Panic Disorder","status":"NOT_YET_RECRUITING","sponsor":"Sultan Qaboos University","startDate":"2023-12-30","conditions":"Panic Disorder","enrollment":80},{"nctId":"NCT03636958","phase":"NA","title":"Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy","status":"WITHDRAWN","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2021-02-15","conditions":"Refractory Epilepsy","enrollment":""},{"nctId":"NCT02374567","phase":"PHASE3","title":"Pharmacovigilance in Gerontopsychiatric Patients","status":"TERMINATED","sponsor":"Hannover Medical School","startDate":"2015-01","conditions":"Dementia, Depression, Schizophrenia","enrollment":407},{"nctId":"NCT02205931","phase":"PHASE4","title":"Ketogenic Diet in Infants With Epilepsy (KIWE)","status":"UNKNOWN","sponsor":"University College, London","startDate":"2015-01","conditions":"Epilepsy","enrollment":160},{"nctId":"NCT00552526","phase":"PHASE4","title":"Ketogenic Diet vs.Antiepileptic Drug Treatment in Drug Resistant Epilepsy","status":"UNKNOWN","sponsor":"Oslo University Hospital","startDate":"2007-11","conditions":"Epilepsy, Mental Retardation","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":270,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Association of two anti-epileptic drugs in first line"],"phase":"phase_3","status":"active","brandName":"Levetiracetam/Clonazepam","genericName":"Levetiracetam/Clonazepam","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination drug pairs levetiracetam, which modulates synaptic vesicle proteins to reduce neuronal excitability, with clonazepam, a benzodiazepine that enhances GABAergic inhibition in the central nervous system. Used for Seizure disorders / Epilepsy (combination therapy), Status epilepticus (acute seizure management).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}