{"id":"leukotriene-receptor-antagonist","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Elevated liver enzymes"},{"rate":null,"effect":"Neuropsychiatric events (rare)"},{"rate":null,"effect":"Gastrointestinal disturbance"}]},"_chembl":{"chemblId":"CHEMBL3642142","moleculeType":"Small molecule","molecularWeight":"422.88"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Leukotrienes are potent inflammatory mediators released by mast cells and eosinophils that promote airway constriction, mucus secretion, and eosinophil recruitment. By antagonizing cysteinyl leukotriene receptors (CysLT1 and CysLT2), these drugs suppress the inflammatory cascade underlying asthma and allergic airway disease. This reduces bronchoconstriction, airway hyperresponsiveness, and eosinophilic inflammation.","oneSentence":"Leukotriene receptor antagonists block cysteinyl leukotriene receptors on airway and immune cells, reducing inflammatory mediator signaling.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:36.027Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (persistent mild to moderate)"},{"name":"Allergic rhinitis"},{"name":"Exercise-induced bronchoconstriction"}]},"trialDetails":[{"nctId":"NCT05922761","phase":"PHASE2","title":"BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)","status":"RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2024-05-31","conditions":"Bronchiolitis Obliterans Syndrome, Bronchiolitis Obliterans, Lung Diseases","enrollment":45},{"nctId":"NCT06850220","phase":"","title":"Observational Study on the Impact of Obstructive Sleep Apnea on Executive Function and Empathy Development 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Used for Asthma (persistent mild to moderate), Allergic rhinitis, Exercise-induced bronchoconstriction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}