{"id":"lercanidipine-enalapril-fixed-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL1200659","moleculeType":"Small molecule","molecularWeight":"492.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lercanidipine is a dihydropyridine calcium channel blocker that prevents calcium influx into vascular smooth muscle cells, causing vasodilation. Enalapril is an ACE inhibitor that blocks the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion. Together, these complementary mechanisms provide synergistic antihypertensive effects.","oneSentence":"This fixed combination reduces blood pressure by blocking calcium channels in vascular smooth muscle (lercanidipine) and inhibiting angiotensin-converting enzyme (enalapril).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:45.096Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT01211314","phase":"PHASE4","title":"Antihypertensive Efficacy of Fixed Combination Drug","status":"TERMINATED","sponsor":"Meir Medical Center","startDate":"2011-01","conditions":"Hypertension","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vasodip Combo 20","hypertension","ambulatory blood pressure monitoring"],"phase":"marketed","status":"active","brandName":"Lercanidipine/enalapril fixed combination","genericName":"Lercanidipine/enalapril fixed combination","companyName":"Meir Medical Center","companyId":"meir-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This fixed combination reduces blood pressure by blocking calcium channels in vascular smooth muscle (lercanidipine) and inhibiting angiotensin-converting enzyme (enalapril). Used for Hypertension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}