{"id":"lercanidipine","rwe":[{"pmid":"41836783","year":"2026","title":"Nephroprotective effect of lercanidipine against gentamicin-induced kidney damage.","finding":"","journal":"Journal of advanced pharmaceutical technology & research","studyType":"Clinical Study"},{"pmid":"41766283","year":"2026","title":"Pharmacokinetic and Bioequivalence Evaluation of Two Lercanidipine Hydrochloride Tablets in Healthy Chinese Volunteers.","finding":"","journal":"Clinical pharmacology in drug development","studyType":"Clinical Study"},{"pmid":"41478047","year":"2026","title":"Capillary blood microsampling and LC-Orbitrap analysis for adherence monitoring of cardiovascular drugs: method development, cross-validation, and patient proof-of-concept using VAMS and Capitainer-B.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"41163212","year":"2025","title":"QbD-driven RP-HPLC method for the simultaneous analysis of dihydropyridines calcium channel blockers in 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Modulators","category":"pharmacology"}],"phase":"phase_3","safety":{"safetySignals":[{"llr":798.231,"date":"","count":1019,"signal":"Acute kidney injury","source":"DrugCentral FAERS","actionTaken":"Reported 1,019 times (LLR=798)"},{"llr":429.97,"date":"","count":440,"signal":"Hyponatraemia","source":"DrugCentral FAERS","actionTaken":"Reported 440 times (LLR=430)"},{"llr":278.058,"date":"","count":461,"signal":"General physical health deterioration","source":"DrugCentral FAERS","actionTaken":"Reported 461 times (LLR=278)"},{"llr":275.82,"date":"","count":280,"signal":"Hyperkalaemia","source":"DrugCentral FAERS","actionTaken":"Reported 280 times (LLR=276)"},{"llr":248.85,"date":"","count":211,"signal":"Lactic acidosis","source":"DrugCentral FAERS","actionTaken":"Reported 211 times (LLR=249)"},{"llr":204.725,"date":"","count":106,"signal":"Pemphigoid","source":"DrugCentral FAERS","actionTaken":"Reported 106 times (LLR=205)"},{"llr":177.72,"date":"","count":256,"signal":"Hypokalaemia","source":"DrugCentral FAERS","actionTaken":"Reported 256 times (LLR=178)"},{"llr":170.107,"date":"","count":108,"signal":"Hypertensive crisis","source":"DrugCentral FAERS","actionTaken":"Reported 108 times (LLR=170)"},{"llr":161.674,"date":"","count":474,"signal":"Hypotension","source":"DrugCentral FAERS","actionTaken":"Reported 474 times (LLR=162)"},{"llr":158.715,"date":"","count":206,"signal":"Drug ineffective","source":"DrugCentral FAERS","actionTaken":"Reported 206 times (LLR=159)"},{"llr":145.08,"date":"","count":511,"signal":"Fall","source":"DrugCentral FAERS","actionTaken":"Reported 511 times (LLR=145)"},{"llr":134.762,"date":"","count":216,"signal":"Bradycardia","source":"DrugCentral FAERS","actionTaken":"Reported 216 times (LLR=135)"},{"llr":128.625,"date":"","count":124,"signal":"Product prescribing error","source":"DrugCentral FAERS","actionTaken":"Reported 124 times (LLR=129)"},{"llr":123.855,"date":"","count":126,"signal":"Cholestasis","source":"DrugCentral FAERS","actionTaken":"Reported 126 times (LLR=124)"},{"llr":123.355,"date":"","count":119,"signal":"Eosinophilia","source":"DrugCentral FAERS","actionTaken":"Reported 119 times (LLR=123)"}],"commonSideEffects":[{"effect":"Acute kidney injury","drugRate":"LLR 798","severity":"serious"},{"effect":"Hyponatraemia","drugRate":"LLR 430","severity":"common"},{"effect":"General physical health deterioration","drugRate":"LLR 278","severity":"common"},{"effect":"Hyperkalaemia","drugRate":"LLR 276","severity":"common"},{"effect":"Lactic acidosis","drugRate":"LLR 249","severity":"common"},{"effect":"Pemphigoid","drugRate":"LLR 205","severity":"common"},{"effect":"Hypokalaemia","drugRate":"LLR 178","severity":"common"},{"effect":"Hypertensive crisis","drugRate":"LLR 170","severity":"common"},{"effect":"Hypotension","drugRate":"LLR 162","severity":"common"},{"effect":"Fall","drugRate":"LLR 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Calcium channels are like the traffic lights that control how much blood can flow through the roads. 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pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4157","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=LERCANIDIPINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LERCANIDIPINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:59:35.093159","biosimilars":[],"competitors":[{"drugName":"amlodipine","drugSlug":"amlodipine","fdaApproval":"1992-07-31","patentExpiry":"Feb 24, 2041","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"felodipine","drugSlug":"felodipine","fdaApproval":"1991-07-25","genericCount":13,"patentStatus":"Off-patent — generic 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It is often used in combination with other medications like hydrochlorothiazide and spironolactone.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}