{"id":"leo43204-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL2109015","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"LEO43204 is a selective retinoid compound formulated as a gel for topical application. It binds to retinoid receptors in the skin, promoting keratinocyte differentiation and reducing inflammatory responses. This mechanism is typical of retinoid-class therapeutics used in inflammatory skin diseases.","oneSentence":"LEO43204 is a topical retinoid that modulates retinoid receptor signaling to reduce inflammation and promote skin cell differentiation in dermatological conditions.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:18:32.180Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Psoriasis"},{"name":"Other inflammatory skin conditions"}]},"trialDetails":[{"nctId":"NCT02549352","phase":"PHASE3","title":"Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Balding Scalp Including 12-month Follow-up","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-11","conditions":"Actinic Keratosis","enrollment":391},{"nctId":"NCT03115476","phase":"PHASE3","title":"A Trial to Compare the Incidence of Squamous Cell Carcinoma (SCC) and Other Skin Neoplasia on Skin Areas Treated With Ingenol Disoxate Gel or Vehicle Gel for Actinic Keratosis on Face and Chest or Scalp","status":"TERMINATED","sponsor":"LEO Pharma","startDate":"2017-06-16","conditions":"Actinic Keratosis, Squamous Cell Carcinoma","enrollment":563},{"nctId":"NCT02547363","phase":"PHASE3","title":"Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Balding Scalp Including 12-month Follow-up","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-11","conditions":"Actinic Keratosis","enrollment":373},{"nctId":"NCT02547233","phase":"PHASE3","title":"Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Face or Chest Including 12-month Follow-up","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-11","conditions":"Actinic Keratosis","enrollment":437},{"nctId":"NCT02549339","phase":"PHASE3","title":"Efficacy and Safety of LEO 43204 in the Field Treatment of Actinic Keratosis on Face or Chest including12-month Follow-up","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-11-13","conditions":"Actinic Keratosis","enrollment":383},{"nctId":"NCT02600598","phase":"PHASE1","title":"Biological Effects of LEO 43204 in Actinic Keratosis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-07","conditions":"Actinic Keratosis","enrollment":24},{"nctId":"NCT02650505","phase":"PHASE1","title":"A Clinical Study to Evaluate the Sensitizing Potential of LEO 43204 Gel","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-02","conditions":"Actinic Keratosis","enrollment":233},{"nctId":"NCT02424305","phase":"PHASE1","title":"Pharmacokinetics of LEO 43204 Gel in Actinic Keratosis Administered Under Maximal Use Conditions","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-05","conditions":"Actinic Keratosis","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":334928,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ingenol Disoxate"],"phase":"phase_3","status":"active","brandName":"LEO43204 gel","genericName":"LEO43204 gel","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LEO43204 gel is a treatment for actinic keratosis, specifically studied for its efficacy and safety in field treatment on the face or chest. The exact mechanism of action of LEO43204 gel is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}