{"id":"leo-90105-calcipotriol-betamethasone-dipropionate","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Skin atrophy (with prolonged use)"},{"rate":null,"effect":"Folliculitis"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL3138708","moleculeType":"Small molecule","molecularWeight":"504.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcipotriol acts as a vitamin D3 receptor agonist, promoting normal differentiation and reducing proliferation of keratinocytes while modulating immune responses in the skin. Betamethasone dipropionate is a Class III corticosteroid that suppresses local inflammatory cytokines and immune cell infiltration. The combination provides synergistic anti-inflammatory and anti-proliferative effects for treating plaque psoriasis.","oneSentence":"LEO 90105 combines a vitamin D analog (calcipotriol) that regulates skin cell differentiation with a potent topical corticosteroid (betamethasone dipropionate) to reduce inflammation and abnormal keratinocyte proliferation in psoriasis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:32.301Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plaque psoriasis (topical treatment)"}]},"trialDetails":[{"nctId":"NCT01422434","phase":"PHASE3","title":"LEO 90105 Ointment in Japanese Subjects With Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2011-07","conditions":"Psoriasis","enrollment":676},{"nctId":"NCT01768013","phase":"PHASE1, PHASE2","title":"The Pharmacokinetics of LEO 90105 (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Japanese Subjects With Extensive Psoriasis Vulgaris","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2012-07","conditions":"Psoriasis Vulgaris","enrollment":13}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["LEO 90105 = Dovobet/Daivobet/Taclonex"],"phase":"phase_3","status":"active","brandName":"LEO 90105 = calcipotriol + betamethasone dipropionate","genericName":"LEO 90105 = calcipotriol + betamethasone dipropionate","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LEO 90105 combines a vitamin D analog (calcipotriol) that regulates skin cell differentiation with a potent topical corticosteroid (betamethasone dipropionate) to reduce inflammation and abnormal keratinocyte proliferation in psoriasis. Used for Plaque psoriasis (topical treatment).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}