{"id":"lenograstim-granogyte-34","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Bone pain"},{"rate":"10-20","effect":"Headache"},{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Fever"},{"rate":"5-10","effect":"Injection site reactions"},{"rate":"5-10","effect":"Splenomegaly"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lenograstim binds to G-CSF receptors on hematopoietic progenitor cells, promoting their maturation into functional neutrophils and releasing them into circulation. This increases neutrophil counts and enhances their antimicrobial activity, helping to prevent or treat neutropenia and associated infections in patients undergoing chemotherapy or bone marrow transplantation.","oneSentence":"Lenograstim is a recombinant human granulocyte colony-stimulating factor (G-CSF) that stimulates the proliferation and differentiation of neutrophil precursor cells in bone marrow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:54.674Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced neutropenia"},{"name":"Bone marrow transplantation support"},{"name":"Severe congenital neutropenia"},{"name":"Mobilization of peripheral blood progenitor cells for autologous transplantation"}]},"trialDetails":[{"nctId":"NCT01107756","phase":"PHASE4","title":"A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen","status":"COMPLETED","sponsor":"Sanofi","startDate":"2010-03","conditions":"Neoplasms (no Otherwise Specified)","enrollment":403}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":50,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"LENOGRASTIM (GRANOGYTE 34)","genericName":"LENOGRASTIM (GRANOGYTE 34)","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lenograstim is a recombinant human granulocyte colony-stimulating factor (G-CSF) that stimulates the proliferation and differentiation of neutrophil precursor cells in bone marrow. Used for Chemotherapy-induced neutropenia, Bone marrow transplantation support, Severe congenital neutropenia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}