{"id":"lenampicillin","rwe":[{"pmid":"32701084","year":"2020","title":"Europium chelate-labeled lateral flow assay for rapid and multiple detection of β-lactam antibiotics by the penicillin-binding protein.","finding":"","journal":"Analytical methods : advancing methods and applications","studyType":"Clinical Study"},{"pmid":"20177059","year":"2010","title":"Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine.","finding":"","journal":"The Journal of biological chemistry","studyType":"Clinical Study"},{"pmid":"19623605","year":"2010","title":"Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"11957126","year":"2002","title":"Differences in postoperative morbidity rates, including infection and dry socket, and differences in the healing process after mandibular third molar surgery in patients receiving 1-day or 3-day prophylaxis with lenampicillin.","finding":"","journal":"Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy","studyType":"Clinical Study"},{"pmid":"10360445","year":"1999","title":"Simple high-performance liquid chromatography determination of ampicillin in human serum using solid-phase extraction disk cartridges.","finding":"","journal":"Journal of chromatography. B, Biomedical sciences and applications","studyType":"Clinical Study"}],"tags":[{"label":"lenampicillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"valacillin","offLabel":[],"synonyms":["valacillin","KBT-1585","KBT 1585","lenampicillin","lenampicillin hydrochloride","lenampicillin HCl"],"timeline":[],"approvals":[],"brandName":"Valacillin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"lenampicillin","explanation":"Imagine your body's cells are like houses, and the bacteria are like construction workers trying to build new houses. Valacillin stops the construction workers from making the walls of the new houses, effectively preventing the bacteria from growing and multiplying.","oneSentence":"Valacillin works by inhibiting bacterial cell wall synthesis.","technicalDetail":"Valacillin exerts its antibacterial effect by inhibiting the transpeptidase enzyme, which is essential for the cross-linking of peptidoglycan in the bacterial cell wall."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1553","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LENAMPICILLIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:17:13.795665","biosimilars":[],"competitors":[],"genericName":"lenampicillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"8M568DM08K","CHEBI":"CHEBI:135748","INN_ID":"5467","UMLSCUI":"C0125457","ChEMBL_ID":"CHEMBL3580454","KEGG_DRUG":"D01696","PUBCHEM_CID":"65646","SECONDARY_CAS_RN":"80734-02-7","MESH_SUPPLEMENTAL_RECORD_UI":"C045384"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":23,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2020 Jul 28","pmid":"32701084","title":"Europium chelate-labeled lateral flow assay for rapid and multiple detection of β-lactam antibiotics by the penicillin-binding protein.","journal":"Analytical methods : advancing methods and applications"},{"date":"2010 Apr 16","pmid":"20177059","title":"Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine.","journal":"The Journal of biological chemistry"},{"date":"2010 Feb","pmid":"19623605","title":"Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development.","journal":"Journal of pharmaceutical sciences"},{"date":"2002 Mar","pmid":"11957126","title":"Differences in postoperative morbidity rates, including infection and dry socket, and differences in the healing process after mandibular third molar surgery in patients receiving 1-day or 3-day prophylaxis with lenampicillin.","journal":"Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy"},{"date":"1999 Apr 30","pmid":"10360445","title":"Simple high-performance liquid chromatography determination of ampicillin in human serum using solid-phase extraction disk cartridges.","journal":"Journal of chromatography. B, Biomedical sciences and applications"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Valacillin is a small molecule antibiotic. It is also known by the synonyms LENAMPICILINA, LENAMPICILLIN, and LENAMPICILLINE.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}