{"id":"leflunomide-10-milligram-mg","safety":{"commonSideEffects":[{"rate":"13–15%","effect":"Diarrhea"},{"rate":"10–15%","effect":"Elevated liver enzymes (ALT/AST)"},{"rate":"10%","effect":"Alopecia"},{"rate":"9–10%","effect":"Nausea"},{"rate":"10%","effect":"Hypertension"},{"rate":"7–8%","effect":"Respiratory tract infection"},{"rate":"6–8%","effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Leflunomide's active metabolite, teriflunomide, selectively inhibits the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH), which is essential for de novo pyrimidine nucleotide synthesis. This preferentially affects rapidly dividing lymphocytes, which depend heavily on this pathway, leading to reduced T-cell and B-cell proliferation and decreased production of inflammatory cytokines. The drug has both immunosuppressive and anti-inflammatory effects.","oneSentence":"Leflunomide inhibits dihydroorotate dehydrogenase, an enzyme required for pyrimidine synthesis, thereby suppressing T-cell and B-cell proliferation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:46.752Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Active psoriatic arthritis"},{"name":"Active ankylosing spondylitis"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Leflunomide 10 milligram (MG)","genericName":"Leflunomide 10 milligram (MG)","companyName":"P. Verschueren","companyId":"p-verschueren","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Leflunomide inhibits dihydroorotate dehydrogenase, an enzyme required for pyrimidine synthesis, thereby suppressing T-cell and B-cell proliferation. Used for Rheumatoid arthritis, Active psoriatic arthritis, Active ankylosing spondylitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}