{"id":"lbh581","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"10-20%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By inhibiting these enzymes, LBH581 reduces the activity of the PI3K/AKT signaling pathway, which is involved in the regulation of immune cell function. This leads to a decrease in the proliferation and survival of immune cells, resulting in immunosuppressive effects.","oneSentence":"LBH581 is a small molecule inhibitor of the PI3K delta and PI3K gamma enzymes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:41:42.065Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsing forms of multiple sclerosis"}]},"trialDetails":[{"nctId":"NCT01222936","phase":"PHASE2","title":"LBH Phase II in Small Cell Lung Cancer (SCLC)","status":"COMPLETED","sponsor":"Southern Europe New Drug Organization","startDate":"2008-05","conditions":"Small Cell Lung Carcinoma","enrollment":21}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Panobinostat"],"phase":"phase_2","status":"active","brandName":"LBH581","genericName":"LBH581","companyName":"Southern Europe New Drug Organization","companyId":"southern-europe-new-drug-organization","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LBH581 is a small molecule inhibitor of the PI3K delta and PI3K gamma enzymes. Used for Relapsing forms of multiple sclerosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}