{"id":"late-dexamethazone","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Immunosuppression / increased infection risk"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Osteoporosis (with chronic use)"}]},"_chembl":{"chemblId":"CHEMBL1830815","moleculeType":"Small molecule","molecularWeight":"358.78"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexamethasone enters cells and binds to intracellular glucocorticoid receptors, which then translocate to the nucleus and modulate gene transcription. This leads to decreased production of pro-inflammatory cytokines, reduced immune cell activation and proliferation, and suppression of inflammatory responses. The term 'late dexamethasone' likely refers to timing of administration in a specific clinical protocol rather than a distinct mechanism.","oneSentence":"Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors in the cytoplasm.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:51:39.332Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and autoimmune conditions (specific indication unclear from 'late dexamethasone' designation)"},{"name":"Likely used as adjunctive therapy in a defined clinical protocol"}]},"trialDetails":[{"nctId":"NCT06307444","phase":"NA","title":"Ultrasound-Guided Erectro Spinae Plane Block Versus Stellate Ganglion Block for Patients With Upper Limb Acute Herpes Zoster Pain.","status":"COMPLETED","sponsor":"Tanta University","startDate":"2024-03-20","conditions":"Acute Herpes Zoster Pain Managment","enrollment":93},{"nctId":"NCT04528329","phase":"PHASE4","title":"Anosmia and / or Ageusia and Early Corticosteroid Use","status":"UNKNOWN","sponsor":"ClinAmygate","startDate":"2021-03-30","conditions":"Covid19, Anosmia","enrollment":300},{"nctId":"NCT04530409","phase":"PHASE4","title":"Timing of Corticosteroids in COVID-19, II. Post COVID-19 Follow-up","status":"UNKNOWN","sponsor":"ClinAmygate","startDate":"2021-03-20","conditions":"Covid19, Corticosteroids","enrollment":752}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dexamethasone"],"phase":"marketed","status":"active","brandName":"Late dexamethazone","genericName":"Late dexamethazone","companyName":"ClinAmygate","companyId":"clinamygate","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors in the cytoplasm. Used for Inflammatory and autoimmune conditions (specific indication unclear from 'late dexamethasone' designation), Likely used as adjunctive therapy in a defined clinical protocol.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}