{"id":"latanoprost-ratiopharm-latanoprost-eyedrops","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Increased iris pigmentation (darkening)"},{"rate":"25-35","effect":"Conjunctival hyperemia (redness)"},{"rate":"3-10","effect":"Eyelash growth (hypertrichosis)"},{"rate":"5-10","effect":"Eye irritation or discomfort"},{"rate":"5-10","effect":"Periocular skin darkening"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Latanoprost acts as a selective agonist of the prostaglandin F (FP) receptor located on ciliary muscle bundle cells in the eye. By activating these receptors, it enhances drainage of aqueous humor through the unconventional uveoscleral pathway, reducing intraocular pressure. This mechanism makes it effective for treating glaucoma and ocular hypertension.","oneSentence":"Latanoprost is a prostaglandin F2α analog that binds to prostaglandin F receptors in the eye to increase uveoscleral outflow of aqueous humor, thereby lowering intraocular pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:52.661Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT01580254","phase":"PHASE4","title":"Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma","status":"UNKNOWN","sponsor":"University of Catanzaro","startDate":"2011-06","conditions":"Intraocular Pressure (IOP), Tear Break-Up Time","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Latanoprost RATIOPHARM© eyedrops (RATIOPHARM GmbH - Ulm, Germany)","authorization number:","039468018/M"],"phase":"marketed","status":"active","brandName":"Latanoprost RATIOPHARM© latanoprost eyedrops","genericName":"Latanoprost RATIOPHARM© latanoprost eyedrops","companyName":"University of Catanzaro","companyId":"university-of-catanzaro","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Latanoprost is a prostaglandin F2α analog that binds to prostaglandin F receptors in the eye to increase uveoscleral outflow of aqueous humor, thereby lowering intraocular pressure. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}