{"id":"lasix-onyu","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (at high doses)"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL35","moleculeType":"Small molecule","molecularWeight":"330.75"},"_dailymed":{"setId":"cb27654f-c7a1-4796-ab08-60a5fa16f5c0","title":"LASIX ONYU (FUROSEMIDE) INJECTION [SQ INNOVATION, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Furosemide blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium, potassium, and chloride. This leads to increased urine output and reduced fluid volume in the body, lowering blood pressure and reducing edema. It is one of the most potent diuretics available and is commonly used in conditions requiring rapid fluid removal.","oneSentence":"Lasix (furosemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:37.454Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema associated with congestive heart failure"},{"name":"Edema associated with hepatic cirrhosis"},{"name":"Edema associated with renal disease"},{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT07269496","phase":"PHASE1","title":"Study to Compare Bioavailability and Pharmacokinetics of a Novel Furosemide Regimen Administered Subcutaneously Versus the Same Dose (80 mg) Administered Intravenously in Healthy Volunteers","status":"COMPLETED","sponsor":"SQ Innovation, Inc.","startDate":"2026-02-09","conditions":"Healthy","enrollment":13},{"nctId":"NCT07018297","phase":"PHASE3","title":"Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2026-02","conditions":"Heart Failure, Acute Decompensated Heart Failure","enrollment":250},{"nctId":"NCT06979726","phase":"PHASE4","title":"Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening Heart Failure","status":"RECRUITING","sponsor":"University of Florida","startDate":"2025-11-20","conditions":"Heart Failure, Volume Overload","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[{"date":"20251007","type":"ORIG","sponsor":"SQ INNOVATION","applicationNumber":"NDA217294"}],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lasix ONYU","genericName":"Lasix ONYU","companyName":"University of Florida","companyId":"university-of-florida","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lasix (furosemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes. Used for Edema associated with congestive heart failure, Edema associated with hepatic cirrhosis, Edema associated with renal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}