{"id":"lasix-25","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (at high doses)"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Furosemide blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium, potassium, and chloride. This increases osmotic pressure in the tubular lumen, drawing water into the urine and producing rapid diuresis. The drug is highly potent and commonly used to reduce fluid overload in cardiac and renal conditions.","oneSentence":"Lasix (furosemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:47.349Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema associated with congestive heart failure"},{"name":"Edema associated with hepatic cirrhosis"},{"name":"Edema associated with renal disease"},{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT07469722","phase":"PHASE2, PHASE3","title":"POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2026-03-23","conditions":"Acute Heart Failure (AHF), Congestive Heart Failure Acute, Diuretic 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(AML) Patients","status":"COMPLETED","sponsor":"Actinium Pharmaceuticals","startDate":"2012-10","conditions":"AML","enrollment":40},{"nctId":"NCT05768360","phase":"PHASE1","title":"A Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Digoxin, Rosuvastatin, Metformin, and Furosemide in Healthy Male Subjects","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2023-04-25","conditions":"Healthy Male Subjects","enrollment":6},{"nctId":"NCT05580510","phase":"PHASE2, PHASE3","title":"\" Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD \"","status":"UNKNOWN","sponsor":"Instituto Nacional de Cardiologia Ignacio Chavez","startDate":"2023-02-06","conditions":"Congenital Heart Disease, Heart Failure, Heart Failure With Reduced Ejection Fraction","enrollment":160},{"nctId":"NCT04049045","phase":"PHASE2","title":"Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure","status":"COMPLETED","sponsor":"Christian Schulze","startDate":"2019-09-29","conditions":"Acute Decompensated Heart Failure","enrollment":60},{"nctId":"NCT03226457","phase":"PHASE4","title":"SGLT2 Inhibition in Combination With Diuretics in Heart Failure","status":"COMPLETED","sponsor":"University of Dundee","startDate":"2017-12-11","conditions":"Heart Failure, Type 2 Diabetes Mellitus","enrollment":23},{"nctId":"NCT04785755","phase":"PHASE2","title":"Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites","status":"COMPLETED","sponsor":"Hala Abd EL-Tawab Ibrahim Radwan","startDate":"2017-11-30","conditions":"Hepatic Ascites","enrollment":90},{"nctId":"NCT00421863","phase":"PHASE4","title":"Italian Study on the Cardiovascular Effects of Systolic Blood Pressure Control - CARDIOSIS Study","status":"COMPLETED","sponsor":"Heart Care 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Percent","enrollment":4},{"nctId":"NCT02458157","phase":"PHASE4","title":"Forced Fluid Removal in High Risk Acute Kidney Injury","status":"TERMINATED","sponsor":"Nordsjaellands Hospital","startDate":"2015-10","conditions":"Acute Kidney Injury, Fluid Overload, Critical Illness","enrollment":21},{"nctId":"NCT02030314","phase":"PHASE4","title":"The Management of Resistant Hypertension in Kidney Transplant Patients Using Chlorthalidone","status":"WITHDRAWN","sponsor":"Virginia Commonwealth University","startDate":"2013-07","conditions":"Resistant Hypertension in Kidney Transplant Patients","enrollment":""},{"nctId":"NCT02905760","phase":"PHASE3","title":"Efficacy of Furosemide Versus Vascular Filling in Patients With Acute Myocardial Infarction","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2016-12","conditions":"Acute Myocardial Infarction With Right Ventricular Extension","enrollment":88},{"nctId":"NCT00554580","phase":"PHASE3","title":"Continuous Positive Airway Pressure for Acute Pulmonary Edema","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2004-10","conditions":"Pulmonary Edema, Dyspnea, Paroxysmal","enrollment":208}],"_emaApprovals":[],"_faersSignals":[{"count":8,"reaction":"DRUG INTERACTION"},{"count":5,"reaction":"RENAL FAILURE ACUTE"},{"count":4,"reaction":"ASTHENIA"},{"count":4,"reaction":"HYPERKALAEMIA"},{"count":4,"reaction":"HYPOTENSION"},{"count":3,"reaction":"ANAEMIA"},{"count":3,"reaction":"MALAISE"},{"count":3,"reaction":"THROMBOCYTOPENIA"},{"count":3,"reaction":"VOMITING"},{"count":2,"reaction":"ABDOMINAL PAIN UPPER"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lasix 25","genericName":"Lasix 25","companyName":"Heart Care Foundation","companyId":"heart-care-foundation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lasix (furosemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes. Used for Edema associated with congestive heart failure, Edema associated with hepatic cirrhosis, Edema associated with renal disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}