{"id":"lansoprazole-pill","safety":{"commonSideEffects":[{"rate":"~12%","effect":"Headache"},{"rate":"~8%","effect":"Diarrhea"},{"rate":"~5%","effect":"Abdominal pain"},{"rate":"~4%","effect":"Nausea"},{"rate":"~3%","effect":"Constipation"}]},"_chembl":{"chemblId":"CHEMBL480","moleculeType":"Small molecule","molecularWeight":"369.37"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lansoprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inactivates the H+/K+-ATPase enzyme in the stomach's parietal cells. This blocks the final step of gastric acid production, significantly reducing intragastric acidity. It is used to treat acid-related disorders by maintaining elevated gastric pH.","oneSentence":"Lansoprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:34.666Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"}]},"trialDetails":[{"nctId":"NCT06778824","phase":"NA","title":"Neuroregulators for the Treatment of Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.","status":"RECRUITING","sponsor":"Hualien Tzu Chi General Hospital","startDate":"2024-04-02","conditions":"Gut-Brain Disorders, GERD Without Erosive Esophagitis","enrollment":610},{"nctId":"NCT05711810","phase":"PHASE4","title":"Medicine-induced Cardiac Hemodialysis on COVID-19","status":"COMPLETED","sponsor":"Yang I. Pachankis","startDate":"2023-01-02","conditions":"Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis, Vaccines","enrollment":1},{"nctId":"NCT02022280","phase":"PHASE1","title":"Effect of Proton Pump Inhibitors on Endothelial Function","status":"COMPLETED","sponsor":"Stanford University","startDate":"2013-03","conditions":"Endothelial Dysfunction","enrollment":21},{"nctId":"NCT01317472","phase":"NA","title":"The Effects of Dexlansoprazole for the Treatment of Throat-Related Reflux","status":"TERMINATED","sponsor":"Indiana University","startDate":"2011-03","conditions":"Laryngopharyngeal Reflux","enrollment":11},{"nctId":"NCT03273634","phase":"PHASE4","title":"The Effect of Proton Pump Inhibition on Palpitations","status":"COMPLETED","sponsor":"Jordan Collaborating Cardiology Group","startDate":"2017-05-20","conditions":"Arrhythmia","enrollment":150},{"nctId":"NCT00685295","phase":"PHASE1, PHASE2","title":"Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2008-08","conditions":"Pain, Fracture, Sprain","enrollment":60},{"nctId":"NCT00442013","phase":"PHASE4","title":"Lansoprazole to Treat Children With Asthma","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2007-03","conditions":"Asthma","enrollment":306},{"nctId":"NCT00369265","phase":"PHASE4","title":"Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux","status":"TERMINATED","sponsor":"American Institute for Voice and Ear Research","startDate":"2006-08","conditions":"Laryngopharyngeal Reflux","enrollment":18},{"nctId":"NCT00335283","phase":"PHASE3","title":"Efficacy of Lansoprazole in Chronic Post Nasal Drip","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2006-08","conditions":"Larynx Disease","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lanzotec"],"phase":"marketed","status":"active","brandName":"Lansoprazole Pill","genericName":"Lansoprazole Pill","companyName":"Jordan Collaborating Cardiology Group","companyId":"jordan-collaborating-cardiology-group","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lansoprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Zollinger-Ellison syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}