{"id":"lamictal-tm","brandName":"Lamictal TM","genericName":"Lamictal TM","companyId":"central-mental-clinic-for-outpatients-of-baku-city","companyName":"Central Mental Clinic for Outpatients of Baku City","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Lamictal (lamotrigine) is an anticonvulsant primarily used for epilepsy and bipolar disorder. It has a unique mechanism of action and is being explored for schizophrenia, though a recent trial was terminated.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lamotrigine blocks sodium channels in a use-dependent manner, which stabilizes the resting membrane potential and reduces the frequency of action potentials. It also inhibits the release of glutamate, the primary excitatory neurotransmitter in the central nervous system. These mechanisms reduce neuronal hyperexcitability and are thought to underlie its anticonvulsant and mood-stabilizing effects.","oneSentence":"Lamictal (lamotrigine) inhibits voltage-gated sodium channels and reduces glutamate release, stabilizing neuronal membranes and reducing excitatory neurotransmission.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Rash (including Stevens-Johnson syndrome risk)"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Ataxia"},{"rate":null,"effect":"Diplopia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"trials":[],"indications":{"approved":[{"name":"Epilepsy (partial seizures, generalized tonic-clonic seizures, Lennox-Gastaut syndrome)"},{"name":"Bipolar I disorder (maintenance treatment to delay time to occurrence of mood episodes)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}