{"id":"lam-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Immunosuppression/increased infection risk"},{"rate":null,"effect":"Stomatitis"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL2108795","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lymphangioleiomyomatosis (LAM) is a rare lung disease characterized by uncontrolled proliferation of smooth muscle-like cells. LAM group compounds are believed to work by inhibiting the mTOR pathway, which is dysregulated in LAM due to TSC1/TSC2 mutations, thereby suppressing aberrant cell growth and proliferation in the lungs and other affected tissues.","oneSentence":"LAM group refers to a class of compounds targeting lymphangioleiomyomatosis-related pathways, likely inhibiting mTOR signaling to reduce abnormal smooth muscle cell proliferation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:18:13.584Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Lymphangioleiomyomatosis (LAM)"}]},"trialDetails":[{"nctId":"NCT06593080","phase":"NA","title":"The DECIDE-TB Trial; Validation of Treatment Decision Algorithms for Childhood Tuberculosis","status":"RECRUITING","sponsor":"Chishala Chabala","startDate":"2024-06-01","conditions":"Tuberculosis, Child Health, HIV","enrollment":30240},{"nctId":"NCT02016924","phase":"PHASE2, PHASE3","title":"Study of Cobicistat-Boosted 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