{"id":"laif-900-bay98-7108","safety":{"commonSideEffects":[{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Drug interactions (CYP3A4 induction)"}]},"_chembl":{"chemblId":"CHEMBL5844461","moleculeType":null,"molecularWeight":"399.50"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Laif 900 contains hyperforin and hypericin as active constituents derived from St. John's Wort (Hypericum perforatum). These compounds inhibit the reuptake of serotonin, norepinephrine, and dopamine, and may also modulate other neurotransmitter pathways. The extract is used as a phytopharmaceutical treatment for mild to moderate depressive symptoms.","oneSentence":"Laif 900 is a standardized St. John's Wort extract that modulates serotonin and other neurotransmitter systems to improve mood in depression.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:08.054Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate depression"}]},"trialDetails":[{"nctId":"NCT04315597","phase":"PHASE3","title":"Study to Learn About Relapse Prevention of Hypericumextract (a Drug Based on the Plant St. John Wort) in Outpatients Suffering From Moderate Depressive Episodes","status":"COMPLETED","sponsor":"Bayer","startDate":"2009-03-03","conditions":"Moderate Depressive Episodes (Major Depression)","enrollment":398}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Laif® 900, BAY98-7108","genericName":"Laif® 900, BAY98-7108","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Laif 900 is a standardized St. John's Wort extract that modulates serotonin and other neurotransmitter systems to improve mood in depression. Used for Mild to moderate depression.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}