{"id":"lactobacillus-plantarum-strain-299v","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (mild)"},{"rate":null,"effect":"Bacteremia or sepsis (rare, in severely immunocompromised patients)"}]},"_chembl":{"chemblId":"CHEMBL2109070","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This live biotherapeutic product colonizes the gastrointestinal tract and produces metabolites that strengthen tight junctions, reduce pathogenic bacterial translocation, and promote regulatory T cell differentiation. By restoring eubiotic balance and reducing systemic inflammation, it may mitigate treatment-related toxicities and support immune homeostasis in pediatric cancer patients undergoing chemotherapy or hematopoietic stem cell transplantation.","oneSentence":"Lactobacillus plantarum strain 299v is a probiotic bacterium that modulates the gut microbiome and enhances intestinal barrier function and immune tolerance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:07.404Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention or mitigation of chemotherapy-induced gastrointestinal toxicity in pediatric cancer patients"},{"name":"Support of immune recovery and reduction of infection risk in pediatric hematopoietic stem cell transplant recipients"}]},"trialDetails":[{"nctId":"NCT03057054","phase":"PHASE3","title":"Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Oncology Group","startDate":"2018-04-30","conditions":"Acute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm, Leukemia","enrollment":173},{"nctId":"NCT06859437","phase":"NA","title":"Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain in Nephrology and Transplantation Department","status":"RECRUITING","sponsor":"Medical University of Silesia","startDate":"2024-10-01","conditions":"Clostridioides Difficile Infection","enrollment":300},{"nctId":"NCT03368105","phase":"NA","title":"Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain","status":"UNKNOWN","sponsor":"Medical University of Silesia","startDate":"2018-01-01","conditions":"Clostridium Difficile","enrollment":300},{"nctId":"NCT01886781","phase":"PHASE4","title":"Effect of Lactobacillus Plantarum 299v on Symptoms of Irritable Bowel Syndrome","status":"COMPLETED","sponsor":"University of Stellenbosch","startDate":"2011-01","conditions":"Irritable Bowel Syndrome","enrollment":81},{"nctId":"NCT01644097","phase":"PHASE2","title":"Probiotic Supplementation in Preventing Treatment-Related Diarrhea in Patients With Cancer Undergoing Chemotherapy","status":"WITHDRAWN","sponsor":"Stanford University","startDate":"2012-11","conditions":"Diarrhea, Unspecified Adult Solid Tumor, Protocol Specific","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DSM 9843","LACTIPLANTIBACILLUS PLANTARUM 299V","Lp 299v"],"phase":"phase_3","status":"active","brandName":"Lactobacillus plantarum strain 299v","genericName":"Lactobacillus plantarum strain 299v","companyName":"Children's Oncology Group","companyId":"children-s-oncology-group","modality":"Biologic","firstApprovalDate":"","aiSummary":"Lactobacillus plantarum strain 299v is a probiotic bacterium that modulates the gut microbiome and enhances intestinal barrier function and immune tolerance. Used for Prevention or mitigation of chemotherapy-induced gastrointestinal toxicity in pediatric cancer patients, Support of immune recovery and reduction of infection risk in pediatric hematopoietic stem cell transplant recipients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}