{"id":"lactobacillus-gg","_chembl":{"chemblId":"CHEMBL2109070","moleculeType":"Unknown"},"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Lactobacillus GG","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T07:05:28.008689+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Lactobacillus Gg","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T07:05:37.244813+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T07:05:35.873207+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lactobacillus GG","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T07:05:36.180252+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2109070/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T07:05:36.902563+00:00"}},"_dailymed":null,"_scrapedAt":"2026-03-27T23:51:25.491Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Lacticaseibacillus_rhamnosus","title":"Lacticaseibacillus rhamnosus","extract":"Lacticaseibacillus rhamnosus is a bacterium that originally was considered to be a subspecies of L. casei, but genetic research found it to be a separate species in the L. casei clade, which also includes L. paracasei and L. zeae. It is a short Gram-positive homofermentative facultative anaerobic non-spore-forming rod that often appears in chains. Some strains of L. rhamnosus bacteria are being used as probiotics, and are particularly useful in treating infections of the female urogenital tract, most particularly very difficult to treat cases of bacterial vaginosis. The species Lacticaseibacillus rhamnosus and Limosilactobacillus reuteri are commonly found in the healthy female genito-urinary tract and are helpful to regain control of dysbiotic bacterial overgrowth during an active infection. L. rhamnosus sometimes is used in dairy products such as fermented milk and as non-starter-lactic acid bacterium (NSLAB) in long-ripened cheese. While frequently considered a beneficial organism, L. rhamnosus may not be as beneficial to certain subsets of the population; in rare circumstances, especially those primarily involving weakened immune system or infants, it may cause endocarditis. Despite the rare infections caused by L. rhamnosus, the species is included in the list of bacterial species with qualified presumed safety (QPS) status of the European Food Safety Agency."},"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T07:05:38.453576+00:00","fieldsConflicting":0,"overallConfidence":0.95},"trialDetails":[{"nctId":"NCT04150380","phase":"PHASE2","title":"Probiotic (LGG) for Veterans With PTSD","status":"COMPLETED","sponsor":"VA Eastern Colorado Health Care System","startDate":"2020-08-24","conditions":"Post Traumatic Stress Disorder, Inflammation","enrollment":383},{"nctId":"NCT06919913","phase":"NA","title":"The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2025-07-12","conditions":"Prosthetic-joint Infection","enrollment":152},{"nctId":"NCT07345585","phase":"NA","title":"Probiotics for Autism Spectrum Disorders: a Randomized Controlled Trial (The PASD Study)","status":"RECRUITING","sponsor":"Federico II University","startDate":"2023-01-01","conditions":"Autism Spectrum Disorder","enrollment":50},{"nctId":"NCT05517928","phase":"NA","title":"A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2023-03-03","conditions":"Healthy","enrollment":30},{"nctId":"NCT07296718","phase":"PHASE4","title":"Single Vs Multi-strain Probiotics for Preterm Neonates","status":"COMPLETED","sponsor":"Madiha, MPhil","startDate":"2023-05-15","conditions":"Necrotizing Enterocolitis of Newborn, Sepsis Newborn, Growth","enrollment":249},{"nctId":"NCT03383874","phase":"PHASE3","title":"A Probiotic Intervention to Prevent Relapse Following Hospitalization for Mania","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2018-09-06","conditions":"Mania (Neurotic)","enrollment":67},{"nctId":"NCT07002489","phase":"NA","title":"Efficacy of Notrande Shuhuajun Probiotic Supplement on Lmproving Constipation in Preschool Children","status":"COMPLETED","sponsor":"Shandong Sibote Biotechnology Co., Ltd.","startDate":"2025-05-30","conditions":"Functional Constipation (FC)","enrollment":102},{"nctId":"NCT04184700","phase":"NA","title":"Epigenetic Effects in Children With Cow's Milk Allergy Treated With Different Formulas","status":"COMPLETED","sponsor":"Federico II University","startDate":"2019-12-10","conditions":"Cow Milk Allergy","enrollment":90},{"nctId":"NCT06751810","phase":"NA","title":"Nutritional Status in Children With Food Allergy: Evaluation of a New Supplement","status":"COMPLETED","sponsor":"Federico II University","startDate":"2024-12-30","conditions":"Food Allergies","enrollment":30},{"nctId":"NCT05178069","phase":"PHASE2","title":"LGG Supplementation in Patients With AUD and ALD","status":"RECRUITING","sponsor":"University of Louisville","startDate":"2022-06-01","conditions":"Alcohol Use Disorder, Alcohol-associated Liver Disease","enrollment":60},{"nctId":"NCT04323735","phase":"PHASE2","title":"Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters","status":"RECRUITING","sponsor":"Medstar Health Research Institute","startDate":"2020-01-10","conditions":"Neurogenic Bladder","enrollment":182},{"nctId":"NCT05467150","phase":"NA","title":"Maternal Probiotic Supplementation for Improved Outcomes in Infants of Diabetic Mothers","status":"RECRUITING","sponsor":"University of Minnesota","startDate":"2022-10-17","conditions":"Infant of Diabetic Mother","enrollment":60},{"nctId":"NCT03196453","phase":"NA","title":"Fit Child - Clinical Study on Weight Control","status":"WITHDRAWN","sponsor":"Turku University Hospital","startDate":"2018-05-25","conditions":"Overweight, Nutrition Disorder, Child, Weight Change, Body","enrollment":""},{"nctId":"NCT07102836","phase":"PHASE2","title":"COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY","status":"RECRUITING","sponsor":"Quaid-e-Azam Medical College","startDate":"2025-08-07","conditions":"Indirect Hyperbilirubinemia, Neonatal","enrollment":110},{"nctId":"NCT07051824","phase":"NA","title":"Probiotic and Prebiotic Use in Early Postoperative Period of Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Ayten Altunsaray","startDate":"2025-01-24","conditions":"Sleeve Gastrectomy, Gastrointestinal Symptoms, Prebiotic","enrollment":60},{"nctId":"NCT06122636","phase":"NA","title":"Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC","status":"COMPLETED","sponsor":"University of Barcelona","startDate":"2022-10-03","conditions":"Quality of Life, Oral Mucositis, Dental Plaque","enrollment":62},{"nctId":"NCT06560879","phase":"PHASE2","title":"Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity in Children with Leukemia","status":"ENROLLING_BY_INVITATION","sponsor":"National Institute of Pediatrics, Mexico","startDate":"2025-02-01","conditions":"Probiotics, Gastrointestinal Diseases, Precursor Cell Lymphoblastic Leukemia-Lymphoma","enrollment":120},{"nctId":"NCT06231706","phase":"NA","title":"ZOE BIOME Study: Biotics Influence on Microbiome Ecosystem","status":"COMPLETED","sponsor":"King's College London","startDate":"2024-01-26","conditions":"Gut Microbiome, Prebiotic, Probiotic","enrollment":399},{"nctId":"NCT04246151","phase":"EARLY_PHASE1","title":"Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients","status":"WITHDRAWN","sponsor":"Hamilton Health Sciences Corporation","startDate":"2022-09-01","conditions":"Clostridium Difficile Colonization, Clostridium Difficile Diarrhea","enrollment":""},{"nctId":"NCT04529980","phase":"NA","title":"Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis","status":"COMPLETED","sponsor":"Children's Health","startDate":"2020-09-08","conditions":"Appendicitis, Appendicitis; Perforation","enrollment":98},{"nctId":"NCT06505330","phase":"NA","title":"Respiratory Tract Microbiome and Probiotics in Children With Cleft Palate","status":"RECRUITING","sponsor":"University Hospital, Antwerp","startDate":"2024-06-24","conditions":"Otitis Media in Children, Cleft Palate Children","enrollment":40},{"nctId":"NCT03861910","phase":"","title":"Dietary Choice for the Management of Cow's Milk Allergy Influences Other Allergic Manifestations","status":"COMPLETED","sponsor":"Federico II University","startDate":"2014-12","conditions":"Allergy Milk, Allergy;Food, Allergic Asthma","enrollment":365},{"nctId":"NCT06464484","phase":"NA","title":"The Effects Of Probiotics On Stress Among Healthy Adults From Umm Al-Qura University At Makkah","status":"COMPLETED","sponsor":"Umm Al-Qura University","startDate":"2023-01-26","conditions":"Stress, Constipation, Anthropometry","enrollment":85},{"nctId":"NCT00113659","phase":"NA","title":"Use of a Probiotic Supplement to Prevent Asthma in Infants","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2005-06","conditions":"Asthma","enrollment":203},{"nctId":"NCT06390176","phase":"NA","title":"Lactobacillus Rhamnosus GG Alleviates Oral Mucositis in Patients Undergoing Radiotherapy","status":"RECRUITING","sponsor":"West China Hospital","startDate":"2023-11-10","conditions":"Oral Mucositis","enrollment":132},{"nctId":"NCT04399252","phase":"NA","title":"Effect of Lactobacillus on the Microbiome of Household Contacts Exposed to COVID-19","status":"COMPLETED","sponsor":"Duke University","startDate":"2020-06-24","conditions":"Microbiome","enrollment":182},{"nctId":"NCT06323642","phase":"NA","title":"Role of Probiotics as Adjunct Therapy Along With Standard Care in Decreasing Hospital Stay and Improving Symptoms in Pediatric Patients Admitted With Severe Pneumonia","status":"RECRUITING","sponsor":"Shaheed Zulfiqar Ali Bhutto Medical University","startDate":"2023-09-01","conditions":"Pneumonia, Probiotics","enrollment":60},{"nctId":"NCT06310733","phase":"PHASE4","title":"The Effects of Probiotics, Lactobacillus GG, in the Treatment of Abdominal Pain in Children With Functional Abdominal Pain Disorders","status":"RECRUITING","sponsor":"Prince of Songkla University","startDate":"2024-03-21","conditions":"Functional Abdominal Pain Syndrome","enrollment":54},{"nctId":"NCT03449537","phase":"NA","title":"Step Down Approach in Children With Cow Milk Allergy","status":"COMPLETED","sponsor":"Federico II University","startDate":"2018-04-01","conditions":"Allergy Milk","enrollment":60},{"nctId":"NCT06252558","phase":"NA","title":"Symbiotic Use in Post-Bariatric Surgery Patients","status":"UNKNOWN","sponsor":"University of North Florida","startDate":"2024-01-08","conditions":"Bariatric Surgery Candidate","enrollment":110},{"nctId":"NCT05165329","phase":"NA","title":"A Randomized, Controlled Trial of Probiotic and Peanut Oral Immunotherapy (PPOIT) in Inducing Tolerance in Hong Kong Children With Peanut Allergy Compared With Oral Immunotherapy (OIT) Alone and With Placebo","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2021-11-11","conditions":"Peanut Allergy, Food Allergy in Children","enrollment":90},{"nctId":"NCT00756262","phase":"PHASE1","title":"Probiotic Lactobacillus GG to Eliminate VRE Colonization","status":"TERMINATED","sponsor":"Tufts Medical Center","startDate":"2003-03","conditions":"Vancomycin Resistant Enterococcal Colonization","enrollment":11},{"nctId":"NCT04487834","phase":"PHASE2","title":"Effects of Vivatlac Baby on Crying Behavior of Colicky Babies","status":"COMPLETED","sponsor":"The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz","startDate":"2020-04-16","conditions":"Infantile Colic","enrollment":87},{"nctId":"NCT06109740","phase":"NA","title":"Probiotics For The Prevention of Antibiotics Associated Diarrhea in the Pediatric Intensive Care Unit","status":"COMPLETED","sponsor":"University of South Alabama","startDate":"2008-10","conditions":"Critical Illness, Antibiotic-associated Diarrhea","enrollment":21},{"nctId":"NCT03477669","phase":"NA","title":"Infantile Colic: Study of the Efficacy of Lactobacillus GG (ATCC 53103) Plus Chamomile in Breastfeeding Infants","status":"TERMINATED","sponsor":"University of Nebraska","startDate":"2018-05-18","conditions":"Infantile Colic","enrollment":1},{"nctId":"NCT04671186","phase":"NA","title":"Role of Probiotics in Treatment of Pediatric NAFLD Patients by Assessing With Fibroscan","status":"COMPLETED","sponsor":"Northwell Health","startDate":"2020-09-07","conditions":"Non-Alcoholic Fatty Liver Disease","enrollment":47},{"nctId":"NCT02819960","phase":"PHASE3","title":"Prevention of Irinotecan Induced Diarrhea by Probiotics","status":"COMPLETED","sponsor":"S&D Pharma SK s.r.o.","startDate":"2016-03","conditions":"Diarrhea, Cancer","enrollment":233},{"nctId":"NCT04102852","phase":"PHASE1, PHASE2","title":"Lactobacillus Rhamnosus GG (ATCC 53103) in Mild-moderately Active UC Patients","status":"COMPLETED","sponsor":"San Giovanni Addolorata Hospital","startDate":"2019-09-30","conditions":"Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate","enrollment":76},{"nctId":"NCT04696718","phase":"NA","title":"Determination of the Biological Activity of Serum From Patients","status":"UNKNOWN","sponsor":"Adeline BLOT","startDate":"2018-12-20","conditions":"Women, Rheumatoid Arthritis","enrollment":20},{"nctId":"NCT05461443","phase":"NA","title":"Lacticaseibacillus Rhamnosus GG Pili Study","status":"COMPLETED","sponsor":"Örebro University, Sweden","startDate":"2016-03-31","conditions":"Healthy","enrollment":10},{"nctId":"NCT03449459","phase":"EARLY_PHASE1","title":"Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract","status":"COMPLETED","sponsor":"Shanghai Zhongshan Hospital","startDate":"2018-12-01","conditions":"Chronic Obstructive Pulmonary Disease (COPD)","enrollment":144},{"nctId":"NCT02046512","phase":"PHASE4","title":"Probiotics to Promote Intestinal Health","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2014-01","conditions":"Communicable Diseases, Infection, Anti-Infective Agents","enrollment":89},{"nctId":"NCT01922895","phase":"NA","title":"Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis","status":"TERMINATED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2013-08-01","conditions":"Acute Alcoholic Hepatitis","enrollment":45},{"nctId":"NCT03832439","phase":"NA","title":"Probiotic Supplementation on Weight Loss","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2019-01-17","conditions":"Bariatric Surgery Candidate","enrollment":18},{"nctId":"NCT02640625","phase":"PHASE1, PHASE2","title":"Improving Prognosis in HIV Infection","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2016-01","conditions":"Human Immunodeficiency Virus","enrollment":20},{"nctId":"NCT00197873","phase":"NA","title":"Lactobacillus Rhamnosus in Prevention of Chemotherapy-related Diarrhoea","status":"COMPLETED","sponsor":"University of Helsinki","startDate":"2005-09","conditions":"Colorectal Cancer","enrollment":84},{"nctId":"NCT05073029","phase":"NA","title":"Open Label Randomized Clinical Study to Promote a Healthy Lifestyle in Medical Students","status":"COMPLETED","sponsor":"Bogomolets National Medical University","startDate":"2019-02-10","conditions":"Healthy, Obesity, Nutrition, Healthy","enrollment":120},{"nctId":"NCT05066152","phase":"NA","title":"The Effect of Single Probiotic on Metabolic Control in Type 2 Diabetes","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2016-02-01","conditions":"Diabetes Mellitus, Type 2","enrollment":34},{"nctId":"NCT02110732","phase":"NA","title":"Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2011-01","conditions":"Upper Respiratory Infection, Acute Otitis Media","enrollment":40},{"nctId":"NCT04836013","phase":"NA","title":"Combined Lactobacilli (Reuteri LMG P-27481 and GG ATCC 53103) to Prevent Antibiotic Associated Symptoms in Children","status":"UNKNOWN","sponsor":"Università degli Studi dell'Insubria","startDate":"2021-05-13","conditions":"Diarrhea Caused by Drug, Abdominal Pain","enrollment":216},{"nctId":"NCT03277820","phase":"NA","title":"Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion","status":"COMPLETED","sponsor":"University Hospital, Antwerp","startDate":"2017-04-03","conditions":"Otitis Media With Effusion, Probiotics, Adenoid Vegetations","enrollment":37},{"nctId":"NCT04144491","phase":"NA","title":"Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in Uganda","status":"COMPLETED","sponsor":"VU University of Amsterdam","startDate":"2019-09-16","conditions":"Respiratory Tract Infections, Diarrhea, Skin Diseases","enrollment":195},{"nctId":"NCT02144701","phase":"NA","title":"Lactobacillus Rhamnosus GG in Reducing Incidence of Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant","status":"COMPLETED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2013-02-18","conditions":"Graft Versus Host Disease","enrollment":33},{"nctId":"NCT04628819","phase":"NA","title":"Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children","status":"TERMINATED","sponsor":"PiLeJe","startDate":"2019-12-29","conditions":"Nosocomial Infection, Diarrhea, Infantile","enrollment":61},{"nctId":"NCT04779281","phase":"NA","title":"Effects of Probiotics and Nutritional Status on Exercise-Induced Symptoms, and Endurance Performance in Ultra-Endurance Athletes","status":"COMPLETED","sponsor":"Istanbul Medeniyet University","startDate":"2018-09-01","conditions":"Ultra-endurance Athletes With Gastrointestinal Symptoms","enrollment":24},{"nctId":"NCT04009889","phase":"NA","title":"Impact of Oral Probiotic Blend on Pregnancy Outcome","status":"COMPLETED","sponsor":"i-Health, Inc.","startDate":"2018-04-05","conditions":"Gestational Diabetes Mellitus in Pregnancy","enrollment":170},{"nctId":"NCT04701775","phase":"NA","title":"Effect of Different Probiotic Strains in Hypercholesterolemic Patients","status":"COMPLETED","sponsor":"Eastern Mediterranean University","startDate":"2018-09-28","conditions":"Hyperlipidemias","enrollment":51},{"nctId":"NCT02462590","phase":"PHASE4","title":"Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial","status":"COMPLETED","sponsor":"McMaster University","startDate":"2015-06","conditions":"Ventilator Associated Pneumonia, Infections, C-Difficile","enrollment":2650},{"nctId":"NCT04666324","phase":"NA","title":"Effects of Multilac Baby on Fecal Calprotectin Levels of Colicky Babies","status":"UNKNOWN","sponsor":"The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz","startDate":"2020-12","conditions":"Infantile Colic","enrollment":100},{"nctId":"NCT03647995","phase":"NA","title":"Probiotics in the Prevention of Antibiotic Induced Diarrhea and Clostridium Difficile Associated Diarrhea.","status":"TERMINATED","sponsor":"Yara El Helou","startDate":"2018-09-01","conditions":"Diarrhea, Clostridium Difficile","enrollment":25},{"nctId":"NCT02748317","phase":"PHASE2","title":"Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB","status":"COMPLETED","sponsor":"Medstar Health Research Institute","startDate":"2016-01","conditions":"Lower Urinary Tract Symptoms","enrollment":96},{"nctId":"NCT02748356","phase":"PHASE2","title":"Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB","status":"COMPLETED","sponsor":"Medstar Health Research Institute","startDate":"2016-01","conditions":"Lower Urinary Tract Symptoms","enrollment":7},{"nctId":"NCT03080818","phase":"NA","title":"Probiotic on Psychological and Cognitive Effects","status":"COMPLETED","sponsor":"Kent State University","startDate":"2017-02-01","conditions":"Aging","enrollment":200},{"nctId":"NCT04277156","phase":"NA","title":"L Rhamnosus ATCC 53103 & L Reuteri DSM 29063 Compared With L Rhamnosus ATCC 53103 for Preventing AAD in Children","status":"UNKNOWN","sponsor":"Medical University of Warsaw","startDate":"2020-02","conditions":"Antibiotic-associated Diarrhea","enrollment":892},{"nctId":"NCT03990220","phase":"","title":"A Nutritional Trial on Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in Uganda","status":"UNKNOWN","sponsor":"VU University of Amsterdam","startDate":"2019-07-01","conditions":"Skin Diseases, Respiratory Tract Infections, Diarrhea","enrollment":1116},{"nctId":"NCT01773967","phase":"PHASE2, PHASE3","title":"Impact of Emergency Department Probiotic (LGG) Treatment of Pediatric Gastroenteritis","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2014-07","conditions":"Gastroenteritis","enrollment":971},{"nctId":"NCT00118872","phase":"NA","title":"Beneficial Bacteria to Prevent Malnutrition and Diarrhea in Pakistani Infants","status":"COMPLETED","sponsor":"Tufts University","startDate":"2006-03","conditions":"Malnutrition, Diarrhea","enrollment":120},{"nctId":"NCT01782755","phase":"PHASE2","title":"Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial","status":"COMPLETED","sponsor":"McMaster University","startDate":"2013-10","conditions":"Ventilator Associated Pneumonia (VAP), Other Infections, Antibiotic-Associated Diarrhea","enrollment":150},{"nctId":"NCT03975569","phase":"NA","title":"Study of the Vaginal Microbiota and the Potential of a Vaginal Probiotic Cream in Vaginal Candidosis","status":"COMPLETED","sponsor":"University Hospital, Antwerp","startDate":"2016-04-04","conditions":"Candidiasis, Vulvovaginal","enrollment":20},{"nctId":"NCT03863418","phase":"NA","title":"Probiotic Lactobacillus Rhamnosus GG for Pediatric Atopic Dermatitis","status":"UNKNOWN","sponsor":"Federico II University","startDate":"2019-05-15","conditions":"Atopic Dermatitis","enrollment":100},{"nctId":"NCT02544685","phase":"PHASE2","title":"Prevention of Febrile Neutropenia by Synbiotics in Pediatric Cancer Patients","status":"UNKNOWN","sponsor":"S&D Pharma SK s.r.o.","startDate":"2010-07","conditions":"Febrile Neutropenia, Neutropenia, Infection in an Immunocompromised Host","enrollment":120},{"nctId":"NCT02711800","phase":"PHASE2","title":"The Probiotic Study: Using Bacteria to Calm Your Mind","status":"COMPLETED","sponsor":"Nancy Zucker","startDate":"2016-11-08","conditions":"Anxiety, Abdominal Pain","enrollment":9},{"nctId":"NCT01616693","phase":"PHASE4","title":"Zinc and/or Probiotic Supplementation of Rotavirus and Oral Polio Virus Vaccines","status":"COMPLETED","sponsor":"PATH","startDate":"2012-07","conditions":"Immunity to Oral Rotavirus Vaccine, Immunity to Oral Polio Vaccine, Shedding of Oral Rotavirus Vaccine","enrollment":620},{"nctId":"NCT01551186","phase":"PHASE4","title":"The Use of Probiotics to Evaluate Colonization With Antimicrobial Resistant Bacteria","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2012-02","conditions":"Infectious Disease of Digestive Tract","enrollment":103},{"nctId":"NCT03100266","phase":"NA","title":"Probiotics for Modic Changes in Low Back Pain Patients","status":"COMPLETED","sponsor":"Ole Kudsk Jensen","startDate":"2016-01-14","conditions":"Low Back Pain","enrollment":94},{"nctId":"NCT01720329","phase":"NA","title":"Use of Probiotics to Prevent Influenza","status":"COMPLETED","sponsor":"McMaster University","startDate":"2013-07","conditions":"Influenza","enrollment":1440},{"nctId":"NCT01788761","phase":"NA","title":"The Effects of Probiotic Supplementation on Extremely Low Birthweight Infants","status":"TERMINATED","sponsor":"Mercy Health System","startDate":"2012-07","conditions":"Feeding Tolerance","enrollment":133},{"nctId":"NCT03078179","phase":"NA","title":"Effect of Lactobacillus Rhamnosus GG and Bifidobacterium Longum in Children Aged 3 to 5 Years of Villavicencio and Pasto","status":"COMPLETED","sponsor":"Cooperative University of Colombia","startDate":"2017-06-05","conditions":"Caries, Dental","enrollment":100},{"nctId":"NCT02719405","phase":"PHASE2","title":"Impact of Infant Formula on Resolution of Cow's Milk Allergy","status":"TERMINATED","sponsor":"Massachusetts General Hospital","startDate":"2016-02","conditions":"Milk Allergy","enrollment":49},{"nctId":"NCT01164124","phase":"PHASE2, PHASE3","title":"Probiotics-Supplemented Feeding in Extremely Low Birth Weight Infants","status":"COMPLETED","sponsor":"Vermont Oxford Network","startDate":"2008-02","conditions":"Low Birth Weight","enrollment":101},{"nctId":"NCT01454661","phase":"NA","title":"Probiotics and Early Microbial Contact in Preterm Neonates","status":"UNKNOWN","sponsor":"Turku University Hospital","startDate":"2014-04","conditions":"Premature; Infant, Light-for-dates, Breastfeeding","enrollment":100},{"nctId":"NCT03256708","phase":"NA","title":"Prevention of Antibiotic-Associated Diarrhoea With Prolardii","status":"UNKNOWN","sponsor":"Therabel Pharma SA/NV","startDate":"2017-10-19","conditions":"Antibiotic-associated Diarrhea","enrollment":220},{"nctId":"NCT02466035","phase":"NA","title":"Epigenetic Effects Involved in Children With Cow's Milk Allergy (EPICMA)","status":"COMPLETED","sponsor":"Federico II University","startDate":"2014-05","conditions":"Cow's Milk Allergy","enrollment":20},{"nctId":"NCT03427515","phase":"NA","title":"Probiotics and Examination-related Stress in Healthy Medical Students","status":"COMPLETED","sponsor":"Medical University of Lodz","startDate":"2016-04-20","conditions":"Healthy, Stress-related Problem, Anxiety","enrollment":92},{"nctId":"NCT01927094","phase":"PHASE4","title":"Effects of Probiotics and/or Prebiotics on the Duration of Diarrhea and Hospitalization in Children","status":"COMPLETED","sponsor":"Eskisehir Osmangazi University","startDate":"2012-06","conditions":"Acute Diarrhea","enrollment":1280},{"nctId":"NCT03310294","phase":"NA","title":"Immune Evidence to the Consumption of Lactobacillus GG and FOS Consumption in Patients With Herpes Labialis","status":"COMPLETED","sponsor":"Sprim Advanced Life Sciences","startDate":"2010-09-14","conditions":"Herpes Labialis","enrollment":157},{"nctId":"NCT03307772","phase":"NA","title":"Immune Response to the Consumption of Lactobacillus GG and FOS in Patients With Recurrent Herpes Labialis","status":"COMPLETED","sponsor":"Sprim Advanced Life Sciences","startDate":"2008-12-15","conditions":"Herpes Labialis","enrollment":78},{"nctId":"NCT01439841","phase":"NA","title":"The Effect of Probiotics in HIV-1 Infection","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2011-10","conditions":"HIV-1 Infection","enrollment":32},{"nctId":"NCT01901380","phase":"","title":"Cow's Milk Allergy and Functional Gastrointestinal Disorders","status":"COMPLETED","sponsor":"Federico II University","startDate":"2013-02","conditions":"Cow's Milk Allergy, Functional Gastrointestinal Disorders","enrollment":220},{"nctId":"NCT03215784","phase":"NA","title":"Gestational Obesity and Interventions With Probiotics or Fish Oil Trial","status":"UNKNOWN","sponsor":"Universidade Federal do Rio de Janeiro","startDate":"2015-03","conditions":"Obesity, Pregnancy, Inflammation","enrollment":80},{"nctId":"NCT03032354","phase":"PHASE4","title":"Probiotics in Newly Recognized Type 1 Diabetes","status":"UNKNOWN","sponsor":"Medical University of Warsaw","startDate":"2017-07-15","conditions":"Diabetes Mellitus, Type 1","enrollment":96},{"nctId":"NCT03168503","phase":"NA","title":"Synbiotic Approach to Immunity and Metabolism in the Elderly Study","status":"COMPLETED","sponsor":"University of Roehampton","startDate":"2013-12","conditions":"Healthy","enrollment":40},{"nctId":"NCT02185092","phase":"NA","title":"Probiotic Use in Patients With Prior COPD Exacerbation","status":"WITHDRAWN","sponsor":"University of Oklahoma","startDate":"2014-10","conditions":"COPD, Obstructive Lung Disease","enrollment":""},{"nctId":"NCT00304863","phase":"PHASE4","title":"Addition of Lactobacillus to Metronidazole in Treatment of CDAD","status":"WITHDRAWN","sponsor":"Michael E. DeBakey VA Medical Center","startDate":"2008-08-01","conditions":"Enterocolitis, Pseudomembranous Colitis, Antibiotic-associated Colitis","enrollment":""},{"nctId":"NCT00895336","phase":"PHASE2","title":"Lactobacillus GG in Pediatric Ulcerative Colitis (UC)","status":"WITHDRAWN","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2011-03","conditions":"Ulcerative Colitis","enrollment":""},{"nctId":"NCT00946283","phase":"NA","title":"Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Myelodysplastic Syndrome","status":"TERMINATED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2010-03","conditions":"Breast Cancer, Chronic Myeloproliferative Disorders, Leukemia","enrollment":30},{"nctId":"NCT01274598","phase":"PHASE1","title":"Study to Evaluate the Safety of Lactobacillus Rhamnosus GG ATCC 53103 (LGG) in Elderly Subjects","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2010-12","conditions":"Healthy, Elderly","enrollment":15},{"nctId":"NCT01368029","phase":"PHASE1","title":"Safety of Lactobacillus Rhamnosus GG Vs. Placebo in Elderly Subjects Receiving Trivalent Inactivated Influenza Vaccine","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2011-09","conditions":"Healthy, Elderly","enrollment":28},{"nctId":"NCT00934453","phase":"PHASE1","title":"Safety of Lactobacillus Rhamnosus GG ATCC 53103 (LGG) in Healthy Volunteers","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2009-12","conditions":"Healthy","enrollment":50},{"nctId":"NCT01545349","phase":"PHASE1","title":"Safety of Lactobacillus Rhamnosus GG Versus Placebo in Elderly Subjects Receiving Live Attenuated Influenza Vaccine","status":"COMPLETED","sponsor":"Patricia L. Hibberd","startDate":"2012-02","conditions":"Healthy, Influenza","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"crossReferences":{"chemblId":"CHEMBL2109070"},"_approvalHistory":[],"publicationCount":285,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Culturelle","Lactobacillus"],"phase":"marketed","status":"active","brandName":"Lactobacillus GG","genericName":"Lactobacillus GG","companyName":"Virginia Commonwealth University","companyId":"virginia-commonwealth-university","modality":"Biologic","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T07:05:38.453576+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":false,"safety":false,"trials":true,"score":1}}