{"id":"lactobacillus-crispatus-m247","safety":{"commonSideEffects":[{"rate":null,"effect":"Vulvovaginal irritation"},{"rate":null,"effect":"Vaginal discharge"},{"rate":null,"effect":"Vulvovaginal discomfort"}]},"_chembl":{"chemblId":"CHEMBL2109070","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This probiotic strain works by establishing dominance of Lactobacillus crispatus in the vaginal microbiota, which produces lactic acid to maintain an acidic pH and inhibit pathogenic bacteria. By restoring eubiosis (healthy microbial balance), it reduces the risk of bacterial vaginosis, urogenital infections, and associated complications. The mechanism relies on competitive exclusion and antimicrobial metabolite production rather than systemic pharmacological activity.","oneSentence":"Lactobacillus crispatus M247 is a live biotherapeutic agent that restores and maintains a healthy vaginal microbiome by colonizing the vaginal tract with beneficial lactobacilli.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:24.775Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial vaginosis"},{"name":"Prevention of recurrent urogenital infections"}]},"trialDetails":[{"nctId":"NCT06857565","phase":"NA","title":"Study to Evaluate the Efficacy of Lactobacillus Crispatus M247 in the Prevention and Treatment of Recurrent Urinary Tract Infections","status":"ACTIVE_NOT_RECRUITING","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2025-03-05","conditions":"Recurrent Urinary Tract Infection","enrollment":84},{"nctId":"NCT06978907","phase":"NA","title":"Evaluation of the Efficacy and Safety of Lactobacillus Crispatus M247 (Crispact®) With Vaginal Laser Therapy in Menopausal Women With Atrophic Vulvovaginitis (VVA)","status":"COMPLETED","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2025-07-01","conditions":"Atrophic Vulvovaginitis","enrollment":75},{"nctId":"NCT06802809","phase":"NA","title":"Efficacy of Probiotic Lactobacillus Crispatus M247 in Promoting High-risk Human Papillomavirus (HR-HPV) Infection Clearance and Modifying Vaginal Microbiota","status":"COMPLETED","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2022-01-05","conditions":"Human Papillomavirus Infection","enrollment":66},{"nctId":"NCT06245486","phase":"NA","title":"Probiotc Lactobacillus Crispatus-M247 (Crispact®) Supplementation in the Sterilization of High-risk Human Papilloma (HPV-HR) Viruses","status":"UNKNOWN","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2024-02-10","conditions":"Human Papillomavirus Infection","enrollment":150},{"nctId":"NCT05871242","phase":"NA","title":"Study to Investigate the Treatment Benefit of Probiotic Lactobacillus Crispatus M247 in Women Undergoing Homologous Level 2 Assisted Reproductive Technology (ART) Procedures","status":"COMPLETED","sponsor":"Dr. Amjad Khan","startDate":"2020-01-10","conditions":"Fertility Issues","enrollment":160},{"nctId":"NCT05808816","phase":"PHASE4","title":"\"Lactobacillus Crispatus M247, LSIL and Microbiota\"","status":"UNKNOWN","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2021-06-16","conditions":"Vaginal Flora Imbalance, ASC-US, LSIL","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lactobacillus Crispatus M247","genericName":"Lactobacillus Crispatus M247","companyName":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","companyId":"fondazione-policlinico-universitario-agostino-gemelli-irccs","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lactobacillus crispatus M247 is a live biotherapeutic agent that restores and maintains a healthy vaginal microbiome by colonizing the vaginal tract with beneficial lactobacilli. Used for Bacterial vaginosis, Prevention of recurrent urogenital infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}