{"id":"lactate-containing-vaginal-lubricant","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL1357","moleculeType":"Small molecule","molecularWeight":"112.06"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lactate mimics the natural lactic acid produced by vaginal lactobacilli, helping to maintain an acidic vaginal environment (pH 3.8–4.5) that supports healthy commensal flora and inhibits pathogenic overgrowth. This physiologic approach reduces vaginal dryness, irritation, and pain during intercourse without systemic hormone absorption.","oneSentence":"A lactate-containing vaginal lubricant maintains vaginal pH and microbial balance to alleviate symptoms of vaginal atrophy and dyspareunia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:04.828Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal atrophy and associated dyspareunia"},{"name":"Vaginal dryness and irritation"}]},"trialDetails":[{"nctId":"NCT05665569","phase":"NA","title":"Effects of Flourish HEC Vaginal Care System on Birth-Related Pelvic Floor Disorders","status":"TERMINATED","sponsor":"Vaginal Biome Science","startDate":"2023-01-30","conditions":"Pelvic Floor Disorders","enrollment":1},{"nctId":"NCT00981305","phase":"PHASE3","title":"Impact of Lactate-Containing Vaginal Lubricant on Sexual Dysfunction in Young Breast Cancer Survivors","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2009-09","conditions":"Sexual Dysfunction, Breast Cancer Survivors","enrollment":136}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clino-san(commercial name in Korea)"],"phase":"phase_3","status":"active","brandName":"Lactate-containing vaginal lubricant","genericName":"Lactate-containing vaginal lubricant","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A lactate-containing vaginal lubricant maintains vaginal pH and microbial balance to alleviate symptoms of vaginal atrophy and dyspareunia. Used for Vaginal atrophy and associated dyspareunia, Vaginal dryness and irritation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}