{"id":"l-methylfolate","safety":{"commonSideEffects":[{"rate":null,"effect":"Insomnia or sleep disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Anxiety or agitation"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":null,"_dailymed":{"setId":"13eb8bf0-5227-455c-9660-b02abee04676","title":"L-METHYLFOLATE CALCIUM (LEVOMEFOLATE CALCIUM) TABLET, COATED [BRYANT RANCH PREPACK]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"L-methylfolate (5-methyltetrahydrofolate) is the predominant circulating form of folate and the primary form that crosses the blood-brain barrier. It serves as a methyl donor in critical biochemical pathways, including the remethylation of homocysteine to methionine and the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. By bypassing the enzymatic conversion step (MTHFR), L-methylfolate is particularly beneficial for individuals with MTHFR polymorphisms or deficiencies.","oneSentence":"L-methylfolate is the active form of folate that directly participates in one-carbon metabolism and methylation reactions essential for DNA synthesis, repair, and neurotransmitter production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:25.964Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Depression (adjunctive treatment, particularly in patients with MTHFR polymorphisms)"},{"name":"Folate deficiency and megaloblastic anemia"},{"name":"Homocysteinemia"},{"name":"Cognitive impairment and age-related cognitive decline"}]},"trialDetails":[{"nctId":"NCT07461649","phase":"NA","title":"Pharmacokinetic Study of Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) After Administration of CreNeuroS® CNS Fish Oil Plus Softgels in Healthy Subjects Under Fasting Conditions","status":"NOT_YET_RECRUITING","sponsor":"Sichuan Credit Pharmaceutical Co., Ltd.","startDate":"2026-03-15","conditions":"Bioavailability and Pharmacokinetics","enrollment":32},{"nctId":"NCT04723836","phase":"NA","title":"Optimal Nutrition for Prevention of Hypertension in Pregnancy","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Ulster","startDate":"2017-03-01","conditions":"Blood Pressure, Pregnancy","enrollment":2250},{"nctId":"NCT05673070","phase":"NA","title":"Use of Ritual Prenatal Multivitamins for Pregnancy","status":"COMPLETED","sponsor":"City University of New York","startDate":"2023-10-15","conditions":"Pregnancy Related, Nutrition, Healthy","enrollment":62},{"nctId":"NCT07013136","phase":"EARLY_PHASE1","title":"Feasibility Test of Folic Acid on Acute Kidney Injury","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-10-01","conditions":"Acute Kidney Injury","enrollment":90},{"nctId":"NCT06218030","phase":"PHASE4","title":"Adjunctive Treatment With L-methylfolate for Treatment-Resistant Generalized Anxiety Disorder: a Pilot Study","status":"RECRUITING","sponsor":"Queen's University","startDate":"2024-10-22","conditions":"Generalized Anxiety Disorder","enrollment":10},{"nctId":"NCT05366933","phase":"PHASE1","title":"B-Complex: A Nutraceutical SANS Countermeasure","status":"RECRUITING","sponsor":"National Aeronautics and Space Administration (NASA)","startDate":"2022-08-01","conditions":"Optic Disc Edema, Endothelial Dysfunction","enrollment":16},{"nctId":"NCT06935630","phase":"NA","title":"Comparison of The Effect of 5-MTHF and Folic Acid Supplementation in Increasing Red Blood Cell Folate in Pregnant Women","status":"RECRUITING","sponsor":"Dr. Soetomo General Hospital","startDate":"2025-01-01","conditions":"Pregnant Women","enrollment":100},{"nctId":"NCT06930144","phase":"NA","title":"5-MTHF Supplementation for Treatment of Type 1 Diabetes Patients","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Changzheng Hospital","startDate":"2025-04","conditions":"Type 1 Diabetes Mellitus","enrollment":34},{"nctId":"NCT06163443","phase":"NA","title":"Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.","status":"COMPLETED","sponsor":"S.LAB (SOLOWAYS)","startDate":"2022-03-02","conditions":"Hyperhomocysteinemia, Hyperlipoproteinemias","enrollment":54},{"nctId":"NCT04974151","phase":"PHASE4","title":"China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype","status":"RECRUITING","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2024-08-22","conditions":"Hypertension, MTHFR 677 TT Genotype","enrollment":24000},{"nctId":"NCT06758778","phase":"NA","title":"CreNeuroS™️CNS Fish Oil Plus Softgels Compared to Vascepa® Capsules and Deplin® Capsules in a Pharmacokinetic, Single Dose Evaluation on Healthy Adult Human Subjects Under Fasting Conditions","status":"ENROLLING_BY_INVITATION","sponsor":"Sichuan Credit Pharmaceutical Co., Ltd.","startDate":"2025-01-03","conditions":"Bioavailability","enrollment":14},{"nctId":"NCT05807711","phase":"PHASE4","title":"Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated with Elevated Serum Homocysteine in Hemodialysis Patients.","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2023-04-01","conditions":"End Stage Renal Disease, Hypertension, Renal","enrollment":51},{"nctId":"NCT06641245","phase":"NA","title":"PREconception Folic Acid Clinical Efficacy (PREFACE) Trial","status":"NOT_YET_RECRUITING","sponsor":"University of British Columbia","startDate":"2025-01-31","conditions":"Folate, Folate Bioavailability, Clinical Trials","enrollment":272},{"nctId":"NCT03059173","phase":"PHASE3","title":"Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian Syndrome","status":"RECRUITING","sponsor":"University Hospital, Lille","startDate":"2023-09-12","conditions":"Polycystic Ovary Syndrome, Reproductive Medicine","enrollment":276},{"nctId":"NCT05699473","phase":"NA","title":"Bioavailability Study of Folate in Healthy Subjects","status":"TERMINATED","sponsor":"Lesaffre International","startDate":"2023-01-12","conditions":"Healthy","enrollment":12},{"nctId":"NCT05931965","phase":"NA","title":"Combination Therapy of Different Antidepressants With Dietary Supplements","status":"COMPLETED","sponsor":"Riphah International University","startDate":"2022-10-05","conditions":"Depression","enrollment":88},{"nctId":"NCT04095052","phase":"NA","title":"Food and Alcohol Behavior Study: Meaningful Enhancement","status":"UNKNOWN","sponsor":"Oklahoma State University Center for Health Sciences","startDate":"2019-08-14","conditions":"Folate Deficiency","enrollment":20},{"nctId":"NCT01687127","phase":"NA","title":"Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA Formation","status":"NOT_YET_RECRUITING","sponsor":"University of British Columbia","startDate":"2024-01-01","conditions":"One-carbon Metabolism in Healthy Individuals","enrollment":25},{"nctId":"NCT02133898","phase":"NA","title":"The Use Of L-Methylfolate As A Treatment For Depression","status":"COMPLETED","sponsor":"University of Florida","startDate":"2016-02","conditions":"Depression","enrollment":57},{"nctId":"NCT04022135","phase":"NA","title":"Natural Folate vs. Synthetic Folic Acid in Pregnancy","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2019-09-16","conditions":"Pregnancy","enrollment":60},{"nctId":"NCT05523115","phase":"NA","title":"An Exploratory Investigation of a Supplement to Promote Cognitive Health Benefits","status":"COMPLETED","sponsor":"Heights","startDate":"2022-06-15","conditions":"Anxiety, Stress, Memory Deficits","enrollment":34},{"nctId":"NCT05434195","phase":"NA","title":"Clinical Antenatal Randomised Study to CharactErise Key Roles of TetrahydroFOLate in HyperTensive Pregnancies","status":"UNKNOWN","sponsor":"University of Oxford","startDate":"2021-06-01","conditions":"Pre-Eclampsia, Pregnancy Induced Hypertension, Pregnancy Related","enrollment":128},{"nctId":"NCT04782037","phase":"PHASE4","title":"Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of Age","status":"UNKNOWN","sponsor":"King Edward Medical University","startDate":"2020-10-21","conditions":"Diarrhoea;Acute","enrollment":324},{"nctId":"NCT01891747","phase":"PHASE1","title":"A Phase I Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma","status":"COMPLETED","sponsor":"Vanderbilt-Ingram Cancer Center","startDate":"2013-07","conditions":"Malignant Glioma","enrollment":14},{"nctId":"NCT05080153","phase":"","title":"Effect of Vitamin Supplementation in Glaucoma Patients","status":"COMPLETED","sponsor":"Devogelaere Vision","startDate":"2019-11-15","conditions":"Glaucoma, Homocysteinemia, Elevated Retinal Venous Pressure","enrollment":26},{"nctId":"NCT03898336","phase":"NA","title":"Eat2beNICE Vitamins and Nutrients as Supplementation for Impulsivity, Irritability, and Compulsivity","status":"UNKNOWN","sponsor":"Radboud University Medical Center","startDate":"2019-09-18","conditions":"Impulsive Behavior","enrollment":210},{"nctId":"NCT00626223","phase":"NA","title":"5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients","status":"COMPLETED","sponsor":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","startDate":"1998-01","conditions":"Mortality, Hyperhomocysteinemia, Inflammation","enrollment":341},{"nctId":"NCT02223299","phase":"NA","title":"Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression.","status":"WITHDRAWN","sponsor":"John D. Dingell VA Medical Center","startDate":"2015-11","conditions":"Depression","enrollment":""},{"nctId":"NCT02837367","phase":"NA","title":"Use of Nutrigenomic Models for the Personalized Treatment With Medical Foods in Obese People","status":"UNKNOWN","sponsor":"University of Medicine and Pharmacy \"Victor Babes\" Timisoara","startDate":"2016-09","conditions":"Obesity, Dyslipidemia","enrollment":600},{"nctId":"NCT02437721","phase":"NA","title":"Suitability of an Infant Formula With L-5-Methyltetrahydrofolate for the Particular Nutritional Use in Infants","status":"COMPLETED","sponsor":"dsm-firmenich Switzerland AG","startDate":"2015-05","conditions":"Growth and Development","enrollment":360},{"nctId":"NCT01381354","phase":"PHASE1","title":"Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)","status":"COMPLETED","sponsor":"University of Iowa","startDate":"2010-10","conditions":"Multiple Sclerosis","enrollment":38},{"nctId":"NCT01853280","phase":"PHASE2, PHASE3","title":"L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD Adults","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2014-05","conditions":"Attention Deficit Hyperactivity Disorder","enrollment":47},{"nctId":"NCT02159261","phase":"","title":"Assess Satisfaction of Patients and Physicians With Results of Yaz Plus Treatment for 13 Cycles","status":"COMPLETED","sponsor":"Bayer","startDate":"2014-07-15","conditions":"Contraception","enrollment":1500},{"nctId":"NCT00955955","phase":"PHASE4","title":"Study of 6(S)-5-MTHF Among Selective Serotonin Reuptake Inhibitor-Resistant Outpatients With Major Depressive Disorder","status":"COMPLETED","sponsor":"George I. Papakostas","startDate":"2009-07","conditions":"Depression","enrollment":75},{"nctId":"NCT01360996","phase":"PHASE4","title":"Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism","status":"COMPLETED","sponsor":"Woman's","startDate":"2011-08","conditions":"Polycystic Ovary Syndrome","enrollment":64},{"nctId":"NCT02696512","phase":"PHASE1, PHASE2","title":"A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness","status":"UNKNOWN","sponsor":"International Brain Research Foundation","startDate":"2016-03","conditions":"Brain Injury","enrollment":30},{"nctId":"NCT01091506","phase":"NA","title":"A Placebo-Controlled Study of Physiologic Effects of L-methylfolate in Schizophrenia Patients","status":"COMPLETED","sponsor":"Pamlab, Inc.","startDate":"2010-03","conditions":"Schizophrenia","enrollment":55},{"nctId":"NCT00941057","phase":"PHASE1","title":"Bioequivalence Study: 2 mg Estradiol Valerate (EV) and 3 mg Dienogest (DNG) Without and With Levomefolate Calcium","status":"COMPLETED","sponsor":"Bayer","startDate":"2009-09","conditions":"Pharmacology, Clinical","enrollment":43},{"nctId":"NCT01902264","phase":"PHASE3","title":"Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception","status":"COMPLETED","sponsor":"Bayer","startDate":"2013-08","conditions":"Contraception","enrollment":34},{"nctId":"NCT01976676","phase":"PHASE2, PHASE3","title":"Folic Acid vs 5-methyltetrahydrofolate (5MTHF) in Recurrent Abortion","status":"COMPLETED","sponsor":"National Nutrition and Food Technology Institute","startDate":"2011-04","conditions":"Recurrent Abortion","enrollment":220},{"nctId":"NCT00853879","phase":"NA","title":"An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease","status":"TERMINATED","sponsor":"Northwell Health","startDate":"2006-12","conditions":"Parkinson's Disease","enrollment":150},{"nctId":"NCT00372645","phase":"NA","title":"Increasing Folate Status of a General Population(FOLSUPP STUDY)","status":"COMPLETED","sponsor":"Quadram Institute Bioscience","startDate":"2005-05","conditions":"Healthy","enrollment":180},{"nctId":"NCT01570088","phase":"PHASE2","title":"Bioavailability of Folic Acid Fortified Bread","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2012-04","conditions":"Red Blood Cell Folate","enrollment":45},{"nctId":"NCT00400387","phase":"PHASE3","title":"Effectiveness of Dalteparin Therapy as Intervention in Recurrent Pregnancy Loss","status":"COMPLETED","sponsor":"University of Jena","startDate":"2006-11","conditions":"Abortion, Habitual","enrollment":449},{"nctId":"NCT01331655","phase":"PHASE3","title":"Clinical Study of a Conventional and Flexible Extended Oral Contraceptive of EE/DRSP With or Without Metafolin in Latin America","status":"WITHDRAWN","sponsor":"Bayer","startDate":"2013-04","conditions":"Contraception","enrollment":""},{"nctId":"NCT01369030","phase":"","title":"Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support)","status":"COMPLETED","sponsor":"Pamlab, Inc.","startDate":"2010-11","conditions":"Major Depressive Disorder","enrollment":554},{"nctId":"NCT00468481","phase":"PHASE3","title":"Efficacy and Safety Study for an Oral Contraceptive Containing Folate","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-04","conditions":"Neural Tube Defects, Contraception, Oral Contraceptives (OC)","enrollment":385},{"nctId":"NCT01031355","phase":"PHASE1","title":"Bioequivalence Study: 3 mg Estradiol Valerate (EV) With and Without Levomefolate Calcium","status":"COMPLETED","sponsor":"Bayer","startDate":"2009-12","conditions":"Contraception, Ovulation Inhibition","enrollment":42},{"nctId":"NCT00933998","phase":"NA","title":"Restoration of Cutaneous Sensorum in Patients With Diabetic Peripheral Neuropathy (DPN) Via Metanx®","status":"COMPLETED","sponsor":"Carolina Musculoskeletal Institute","startDate":"2006-06","conditions":"Diabetic Peripheral Neuropathy","enrollment":20},{"nctId":"NCT01001559","phase":"","title":"Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis","status":"COMPLETED","sponsor":"Pamlab, Inc.","startDate":"2009-08","conditions":"Major Depressive Disorder","enrollment":242},{"nctId":"NCT01258660","phase":"PHASE1","title":"Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of Folate","status":"COMPLETED","sponsor":"Bayer","startDate":"2006-12","conditions":"Contraception","enrollment":172},{"nctId":"NCT00726713","phase":"PHASE4","title":"Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN)","status":"COMPLETED","sponsor":"Pamlab, Inc.","startDate":"2008-06","conditions":"Type 2 Diabetic Peripheral Neuropathy (DPN)","enrollment":214},{"nctId":"NCT01253174","phase":"PHASE1","title":"Investigation of Bioequivalence of Ethinylestradiol (EE) and Drospirenone (DRSP) in Two Different Tablet Formulations: Yasmin and Yasmin + Levomefolate Calcium (Metafolin) & L-5-MTHF in Two Different Tablet Formulations: Levomefolate Calcium (Metafolin) and Yasmin + Levomefolate Calcium (Metafolin)","status":"COMPLETED","sponsor":"Bayer","startDate":"2006-08","conditions":"Contraception","enrollment":48},{"nctId":"NCT01253187","phase":"PHASE1","title":"Investigation of Bioequivalence of Ethinylestradiol (EE) and Drospirenone (DRSP) in Two Different Tablet Formulations: YAZ and YAZ + Levomefolate Calcium (Metafolin) & L-5-MTHF in Two Different Tablet Formulations: Levomefolate Calcium (Metafolin) and YAZ + Levomefolate Calcium (Metafolin)","status":"COMPLETED","sponsor":"Bayer","startDate":"2006-10","conditions":"Contraception","enrollment":44},{"nctId":"NCT01370954","phase":"","title":"NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)","status":"COMPLETED","sponsor":"Pamlab, Inc.","startDate":"2011-05","conditions":"Early Memory Loss, Mild Cognitive Impairment, Alzheimer's Disease","enrollment":204},{"nctId":"NCT01358552","phase":"","title":"Néevo®/NéevoDHA® P.L.U.S. Program (Progress Through Learning, Understand & Support)","status":"TERMINATED","sponsor":"Pamlab, Inc.","startDate":"2011-01","conditions":"Pregnancy","enrollment":53},{"nctId":"NCT01062958","phase":"","title":"A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy","status":"COMPLETED","sponsor":"Pamlab, Inc.","startDate":"2009-12","conditions":"Anemia in Pregnancy, Preeclampsia","enrollment":100},{"nctId":"NCT00348933","phase":"NA","title":"Dietary Supplements for the Treatment of Angelman Syndrome","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2006-07","conditions":"Angelman Syndrome, Nervous System Diseases","enrollment":90},{"nctId":"NCT01584050","phase":"NA","title":"Relative Bioavailability of Folic Acid and L-5-Methlytetrahydrofolate","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2012-05","conditions":"Vitamin B12 Deficiency","enrollment":150},{"nctId":"NCT01247558","phase":"","title":"Administrative Claims Analysis of Metanx® in Diabetic Peripheral Neuropathy","status":"COMPLETED","sponsor":"Pamlab, L.L.C.","startDate":"2010-11","conditions":"Diabetic Peripheral Neuropathy (DPN)","enrollment":500},{"nctId":"NCT01368549","phase":"","title":"Metanx® P.L.U.S. Program (Progress Through Learning, Understanding & Support)","status":"UNKNOWN","sponsor":"Pamlab, L.L.C.","startDate":"2011-01","conditions":"Diabetic Peripheral Neuropathy","enrollment":800},{"nctId":"NCT01193192","phase":"","title":"A Retrospective Analysis of Neevo® and NeevoDHA® Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy","status":"TERMINATED","sponsor":"Pamlab, L.L.C.","startDate":"2010-07","conditions":"Anemia in Pregnancy, Pre-eclampsia","enrollment":30},{"nctId":"NCT00321152","phase":"PHASE4","title":"A Study of 6(S)-5-MTHF Among Serotonin Reuptake Inhibitor(SSRI)-Resistant Outpatients With Major Depressive Disorder (MDD)","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2006-11","conditions":"Major Depressive Disorder","enrollment":150},{"nctId":"NCT00730509","phase":"NA","title":"Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis","status":"COMPLETED","sponsor":"Universita di Verona","startDate":"2004-04","conditions":"Cystic Fibrosis","enrollment":31}],"_emaApprovals":[],"_faersSignals":[{"count":55,"reaction":"NAUSEA"},{"count":45,"reaction":"HEADACHE"},{"count":44,"reaction":"ANXIETY"},{"count":43,"reaction":"FATIGUE"},{"count":38,"reaction":"DEPRESSION"},{"count":37,"reaction":"DRUG INEFFECTIVE"},{"count":34,"reaction":"DIZZINESS"},{"count":32,"reaction":"PAIN"},{"count":31,"reaction":"DIARRHOEA"},{"count":31,"reaction":"VOMITING"}],"_approvalHistory":[],"publicationCount":109,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Deplin®","Deplin"],"phase":"marketed","status":"active","brandName":"L-methylfolate","genericName":"L-methylfolate","companyName":"Queen's University","companyId":"queen-s-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L-methylfolate is the active form of folate that directly participates in one-carbon metabolism and methylation reactions essential for DNA synthesis, repair, and neurotransmitter production. Used for Depression (adjunctive treatment, particularly in patients with MTHFR polymorphisms), Folate deficiency and megaloblastic anemia, Homocysteinemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}