{"id":"l-e-maxillary-anesthesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Injection site discomfort"},{"rate":null,"effect":"Allergic reaction (rare with amide anesthetics)"}]},"_chembl":{"chemblId":"CHEMBL1672701","moleculeType":"Small molecule","molecularWeight":"470.46"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This appears to be a combination local anesthetic preparation (likely lidocaine and epinephrine based on the 'L+E' designation) intended for maxillary nerve block or infiltration anesthesia in dental and oral surgical procedures. The formulation combines a local anesthetic agent with a vasoconstrictor to prolong duration and reduce systemic absorption.","oneSentence":"L+E maxillary anesthesia is a local anesthetic formulation designed to provide regional anesthesia in the maxillary region of the oral cavity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:18:01.973Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for maxillary dental and oral surgical procedures"}]},"trialDetails":[{"nctId":"NCT02371759","phase":"PHASE3","title":"Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2","status":"COMPLETED","sponsor":"University of Belgrade","startDate":"2013-06","conditions":"Diabetes Mellitus, Local Anesthesia","enrollment":256}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"L+E maxillary anesthesia","genericName":"L+E maxillary anesthesia","companyName":"University of Belgrade","companyId":"university-of-belgrade","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L+E maxillary anesthesia is a local anesthetic formulation designed to provide regional anesthesia in the maxillary region of the oral cavity. Used for Local anesthesia for maxillary dental and oral surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}