{"id":"l-e-mandibular-anesthesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Hematoma at injection site"},{"rate":null,"effect":"Temporary numbness beyond intended duration"},{"rate":null,"effect":"Allergic reaction (rare with amide anesthetics)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This formulation combines local anesthetic agents (likely lidocaine and epinephrine based on the 'L+E' designation) to block nerve conduction in the mandibular division of the trigeminal nerve, producing sensory anesthesia of the lower jaw, teeth, and associated tissues. The epinephrine component acts as a vasoconstrictor to prolong anesthetic duration and reduce systemic absorption of the local anesthetic agent.","oneSentence":"L+E mandibular anesthesia is a local anesthetic formulation designed to provide regional anesthesia of the mandibular nerve for dental and oral surgical procedures.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:49:11.000Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mandibular nerve block for dental anesthesia"},{"name":"Regional anesthesia for oral and maxillofacial surgery"}]},"trialDetails":[{"nctId":"NCT02371759","phase":"PHASE3","title":"Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2","status":"COMPLETED","sponsor":"University of Belgrade","startDate":"2013-06","conditions":"Diabetes Mellitus, Local Anesthesia","enrollment":256}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"L+E mandibular anesthesia","genericName":"L+E mandibular anesthesia","companyName":"University of Belgrade","companyId":"university-of-belgrade","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L+E mandibular anesthesia is a local anesthetic formulation designed to provide regional anesthesia of the mandibular nerve for dental and oral surgical procedures. Used for Mandibular nerve block for dental anesthesia, Regional anesthesia for oral and maxillofacial surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}