{"id":"l-arginine-and-liposomal-vitamin-c","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL212301","moleculeType":"Small molecule","molecularWeight":"174.20"},"_fixedAt":"2026-03-30T11:42:28.975346","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"L-arginine is a semi-essential amino acid that serves as a substrate for nitric oxide synthase, promoting vasodilation and improving endothelial function. Liposomal vitamin C (ascorbic acid in liposomal formulation) enhances bioavailability and provides antioxidant effects, potentially reducing oxidative stress and supporting immune responses. Together, these agents may work synergistically to improve vascular health and reduce inflammatory markers.","oneSentence":"L-arginine enhances nitric oxide production to improve vascular function, while liposomal vitamin C provides antioxidant support and may enhance immune function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:00.853Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"COVID-19 (phase 3 trial context)"},{"name":"Vascular dysfunction and endothelial dysfunction"}]},"_fixedFields":["pubmed(3)"],"trialDetails":[{"nctId":"NCT06439875","phase":"NA","title":"Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation.","status":"COMPLETED","sponsor":"Istituti Clinici Scientifici Maugeri SpA","startDate":"2024-07-16","conditions":"Chronic Obstructive Pulmonary Disease, Respiratory Failure","enrollment":101},{"nctId":"NCT06865261","phase":"NA","title":"Effects of L-ARGinine and Liposomal Vitamin C Supplementation On Physical Performance","status":"RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2024-05-20","conditions":"Sarcopenia","enrollment":100},{"nctId":"NCT06044194","phase":"PHASE3","title":"Evaluation of the Effect of Liposomal L-Arg and Vit C Integration on Mitochondrial Function in Patients With Heart Failure","status":"RECRUITING","sponsor":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","startDate":"2023-03-21","conditions":"Heart Failure","enrollment":56},{"nctId":"NCT04947488","phase":"NA","title":"Evaluation of the Effects of Treatment With Bioarginin C in Adult Subjects Belonging to the Post-Covid Day Hospital","status":"UNKNOWN","sponsor":"University of Milan","startDate":"2021-06-18","conditions":"Fatigue Syndrome, Chronic, Inflammation","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"recentPublications":[{"date":"2026 Feb 9","pmid":"41718064","title":"The Role of L-Arginine and Liposomal Vitamin C Supplementation as an Adjunct in Seasonal Respiratory Viral Infection Recovery.","journal":"Advances in respiratory medicine"},{"date":"2025 Jun","pmid":"40316462","title":"Impact of L-arginine and liposomal vitamin C supplementation on quality of life and daily life activities in patients with COPD: a randomized, multicenter, single blind, placebo-controlled trial (ILDA study).","journal":"European journal of internal medicine"},{"date":"2022 Nov 23","pmid":"36501014","title":"Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial.","journal":"Nutrients"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"L-arginine and liposomal vitamin C","genericName":"L-arginine and liposomal vitamin C","companyName":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","companyId":"fondazione-irccs-ca-granda-ospedale-maggiore-policlinico","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L-arginine enhances nitric oxide production to improve vascular function, while liposomal vitamin C provides antioxidant support and may enhance immune function. Used for COVID-19 (phase 3 trial context), Vascular dysfunction and endothelial dysfunction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}