{"id":"l-alpha-glycerylphosphorylcholine","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Agitation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"GPC is a choline-containing phospholipid that crosses the blood-brain barrier and serves as a precursor for acetylcholine production, a critical neurotransmitter for cognition and memory. It also enhances phosphatidylcholine synthesis in neuronal membranes, improving membrane integrity and synaptic plasticity. 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LTD.","startDate":"2015-07","conditions":"Alzheimer Disease","enrollment":128},{"nctId":"NCT01363648","phase":"PHASE4","title":"The Efficacy of Gliatiline® on Post-stroke Patients With Vascular Cognitive Impairment no Dementia","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2010-11","conditions":"Cognitive Impairment, Stroke","enrollment":222},{"nctId":"NCT01388738","phase":"PHASE3","title":"Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke.","status":"COMPLETED","sponsor":"Clinical Institute of the Brain, Russia","startDate":"2011-01","conditions":"Stroke","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":51,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"L-Alpha glycerylphosphorylcholine","genericName":"L-Alpha glycerylphosphorylcholine","companyName":"Clinical Institute of the Brain, Russia","companyId":"clinical-institute-of-the-brain-russia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L-Alpha glycerylphosphorylcholine (GPC) is a natural phospholipid precursor that increases acetylcholine synthesis and neuronal membrane fluidity in the brain. Used for Age-related cognitive decline, Dementia and Alzheimer's disease, Stroke recovery and post-stroke cognitive impairment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}