{"id":"l-alanyl-l-glutamine-dipeptide","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Electrolyte imbalance"},{"rate":null,"effect":"Gastrointestinal intolerance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This dipeptide is a conditionally essential amino acid combination that serves as a substrate for protein synthesis and glutamine-dependent cellular processes. It is used to maintain nitrogen balance and support immune function in patients with severe illness, sepsis, or major surgery where endogenous amino acid production is insufficient. The dipeptide formulation allows for improved stability and bioavailability compared to free glutamine.","oneSentence":"L-alanyl-L-glutamine dipeptide provides amino acid supplementation to support protein synthesis, immune function, and cellular metabolism, particularly in critically ill or post-operative patients.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:07.141Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nutritional support in critically ill patients"},{"name":"Post-operative metabolic support"},{"name":"Sepsis-associated malnutrition"}]},"trialDetails":[{"nctId":"NCT04305769","phase":"PHASE2","title":"Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT)","status":"RECRUITING","sponsor":"University of Virginia","startDate":"2021-06-01","conditions":"Clostridioides Difficile Infection, Clostridium Difficile Infection, Clostridium Difficile Diarrhea","enrollment":260},{"nctId":"NCT05822518","phase":"NA","title":"Outcome of Perioperative Immune Enhancing Nutrition in Patients Undergoing Radical Cystectomy","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2022-06-01","conditions":"Cancer, Bladder, Cystostomy; Complications","enrollment":42},{"nctId":"NCT04560309","phase":"PHASE3","title":"Role of Glutamine as Myocardial Protector in Elective On-Pump CABG Surgery With Low EF","status":"COMPLETED","sponsor":"National Cardiovascular Center Harapan Kita Hospital Indonesia","startDate":"2021-01-01","conditions":"Coronary Artery Bypass, Cardiopulmonary Bypass, Coronary Artery Disease","enrollment":60},{"nctId":"NCT06065566","phase":"NA","title":"Effect of Parenteral Glutamine on Myocardial Injury and Inflammation Biomarkers","status":"COMPLETED","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2020-02-04","conditions":"Insufficiency;Cardiac","enrollment":56},{"nctId":"NCT05586646","phase":"NA","title":"Effect of IV Alanyl Glutamine on Healing of Pressure Ulcers in Critically Ill Patients","status":"UNKNOWN","sponsor":"Air Force Specialized Hospital, Cairo, Egypt","startDate":"2022-04-01","conditions":"Pressure Ulcer","enrollment":200},{"nctId":"NCT03341169","phase":"NA","title":"Impact of Perioperative Treatment With Intravenous Glutamine on Myocardial Protection in Cardiac Surgery Patients With Aortic Stenosis","status":"UNKNOWN","sponsor":"Yonsei University","startDate":"2018-03-20","conditions":"Aortic Valve Stenois","enrollment":108},{"nctId":"NCT00248638","phase":"PHASE3","title":"Efficacy and Mechanisms of GLN Dipeptide in the SICU","status":"COMPLETED","sponsor":"Emory University","startDate":"2006-09","conditions":"Critical Illness","enrollment":150},{"nctId":"NCT01353638","phase":"PHASE1, PHASE2","title":"Safety and Efficacy of the Addition of Alanyl-Glutamine-Dipeptide to Dialysis Solution in Peritoneal Dialysis","status":"TERMINATED","sponsor":"Christoph Aufricht","startDate":"2011-04","conditions":"End Stage Renal Disease","enrollment":25},{"nctId":"NCT01794884","phase":"PHASE2","title":"Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery","status":"COMPLETED","sponsor":"Yuejiang Liu","startDate":"2013-01","conditions":"Rheumatic Heart Disease, Coronary Heart Disease","enrollment":33},{"nctId":"NCT01478126","phase":"PHASE3","title":"Effects of Glutamine in Ischemic Heart Disease Patients Following Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Meshalkin Research Institute of Pathology of Circulation","startDate":"2012-01","conditions":"Coronary Artery Disease","enrollment":24},{"nctId":"NCT01831310","phase":"PHASE4","title":"Nutrition for Colorectal Cancer Patients and Neutrophil Functions","status":"COMPLETED","sponsor":"Kocaeli University","startDate":"2007-01","conditions":"Malnutrition, Colorectal Cancer","enrollment":36},{"nctId":"NCT00922688","phase":"NA","title":"Dipeptide Alanyl Glutamine and Postoperative Insulin Resistance in Colon Carcinoma Patients","status":"UNKNOWN","sponsor":"Medical Center Alkmaar","startDate":"2010-12","conditions":"Colon Carcinoma","enrollment":30},{"nctId":"NCT01250782","phase":"PHASE2","title":"Effectiveness of Dipeptide N (2)-L-Alanyl-L-Glutamine in Trauma ICU Patients: Pilot, Prospective, Randomized and Double Blind Study.","status":"UNKNOWN","sponsor":"Hospital Universitari Son Dureta","startDate":"2010-10","conditions":"Trauma ICU Patients","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dipeptiven"],"phase":"phase_3","status":"active","brandName":"L-alanyl-L-glutamine dipeptide","genericName":"L-alanyl-L-glutamine dipeptide","companyName":"National Cardiovascular Center Harapan Kita Hospital Indonesia","companyId":"national-cardiovascular-center-harapan-kita-hospital-indonesia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L-alanyl-L-glutamine dipeptide provides amino acid supplementation to support protein synthesis, immune function, and cellular metabolism, particularly in critically ill or post-operative patients. Used for Nutritional support in critically ill patients, Post-operative metabolic support, Sepsis-associated malnutrition.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}