{"id":"kytril-inj-kytril-tab","safety":{"commonSideEffects":[{"rate":"3-14%","effect":"Headache"},{"rate":"3-18%","effect":"Constipation"},{"rate":"5-18%","effect":"Asthenia/fatigue"},{"rate":"3-13%","effect":"Diarrhea"},{"rate":"2-6%","effect":"Abdominal pain"},{"rate":"2-3%","effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Granisetron is a selective antagonist of serotonin 5-HT3 receptors, which are located on chemoreceptor trigger zone neurons and on the vagal afferent nerves of the gastrointestinal tract. By blocking these receptors, it prevents the transmission of emetic signals to the vomiting center in the brain, effectively suppressing both chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).","oneSentence":"Granisetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:15.768Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Postoperative nausea and vomiting (PONV)"},{"name":"Radiation-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT01659775","phase":"PHASE4","title":"Phase 4 Trial to Evaluate the Efficacy and Safety of Sancuso Patch in Chemotherapy-induced Nausea and Vomiting Associated With the Administration of Highly Emetogenic Chemotherapy (HEC)","status":"COMPLETED","sponsor":"LG Life Sciences","startDate":"2011-08","conditions":"Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV)","enrollment":389},{"nctId":"NCT01662687","phase":"PHASE4","title":"Phase 4 Trial to Evaluate the Efficacy and Safety of Sancuso Patch in CINV (Chemotherapy-induced Nausea and Vomiting) Associated With the Administration of MEC (Moderately Emetogenic Chemotherapy)","status":"UNKNOWN","sponsor":"LG Life Sciences","startDate":"2012-02","conditions":"Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV)","enrollment":276}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Kytril inj.+Kytril tab.","genericName":"Kytril inj.+Kytril tab.","companyName":"LG Life Sciences","companyId":"lg-life-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Granisetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting. Used for Chemotherapy-induced nausea and vomiting (CINV), Postoperative nausea and vomiting (PONV), Radiation-induced nausea and vomiting.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}