{"id":"krypton-81mkr-gas","rwe":[{"pmid":"25882385","year":"2015","title":"Nasal high flow clears anatomical dead space in upper airway models.","finding":"","journal":"Journal of applied physiology (Bethesda, Md. : 1985)","studyType":"Clinical Study"},{"pmid":"19936368","year":"2009","title":"Ventilation and aerosolized drug delivery to the paranasal sinuses using pulsating airflow - a preliminary study.","finding":"","journal":"Rhinology","studyType":"Clinical Study"},{"pmid":"18853874","year":"2008","title":"Ventilation and drug delivery to the paranasal sinuses: studies in a nasal cast using pulsating airflow.","finding":"","journal":"Rhinology","studyType":"Clinical Study"},{"pmid":"16600601","year":"2006","title":"Kr-81m calibration factor for the npl ionisation chamber.","finding":"","journal":"Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine","studyType":"Clinical Study"},{"pmid":"11763175","year":"2001","title":"Comparison of deposition images obtained by use of an ultrafine 99m-technetium-labeled carbon dry aerosol with ventilation images obtained by use of 81m-krypton gas for evaluation of pulmonary dysfunction in calves.","finding":"","journal":"American journal of veterinary research","studyType":"Clinical Study"}],"tags":[{"label":"krypton (81mKr) gas","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V09EX01","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"81kr","offLabel":[],"synonyms":["krypton, Kr-81M","krypton (81mKr) gas","Kr 81","Krypton-81","81Kr","Krypton Kr 81m","Krypton (81m Kr)","Krypton (81mKr)","Krypton-81m"],"timeline":[],"approvals":[],"brandName":"81Kr","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"krypton (81mKr) gas","explanation":"Imagine a special kind of X-ray that uses a gas to see how blood is flowing and where it's being used in the body. This gas emits tiny amounts of radiation that are detected by a scanner, creating detailed images of the body's internal structures. This helps doctors diagnose and monitor conditions like heart disease and stroke.","oneSentence":"81Kr emits gamma rays that are detected by a scanner to create images of the body's blood flow and oxygenation.","technicalDetail":"81Kr is a positron-emitting noble gas that undergoes electron capture decay, emitting gamma rays that are detected by a PET scanner to create images of myocardial blood flow and oxygenation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4584","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=krypton (81mKr) gas","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:59:11.698760","biosimilars":[],"competitors":[{"drugName":"xenon (127Xe) gas","drugSlug":"xenon-(127xe)-gas","fdaApproval":"1982-10-01","relationship":"same-class"},{"drugName":"xenon (133Xe) gas","drugSlug":"xenon-(133xe)-gas","fdaApproval":"","relationship":"same-class"}],"genericName":"krypton (81mkr) gas","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"xenon-(127xe)-gas","brandName":"xenon (127Xe) gas","genericName":"xenon (127Xe) gas","approvalYear":"1982","relationship":"same-class"},{"drugId":"xenon-(133xe)-gas","brandName":"xenon (133Xe) gas","genericName":"xenon (133Xe) gas","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"68QN45K12N","CHEBI":"CHEBI:136002","UMLSCUI":"C0303689","ChEMBL_ID":"CHEMBL1201096","DRUGBANK_ID":"DB09443","PUBCHEM_CID":"66380","MESH_SUPPLEMENTAL_RECORD_UI":"C000615470"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":28,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"V09EX01","allCodes":["V09EX01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2015 Jun 15","pmid":"25882385","title":"Nasal high flow clears anatomical dead space in upper airway models.","journal":"Journal of applied physiology (Bethesda, Md. : 1985)"},{"date":"2009 Dec","pmid":"19936368","title":"Ventilation and aerosolized drug delivery to the paranasal sinuses using pulsating airflow - a preliminary study.","journal":"Rhinology"},{"date":"2008 Sep","pmid":"18853874","title":"Ventilation and drug delivery to the paranasal sinuses: studies in a nasal cast using pulsating airflow.","journal":"Rhinology"},{"date":"2006 Oct-Nov","pmid":"16600601","title":"Kr-81m calibration factor for the npl ionisation chamber.","journal":"Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine"},{"date":"2001 Dec","pmid":"11763175","title":"Comparison of deposition images obtained by use of an ultrafine 99m-technetium-labeled carbon dry aerosol with ventilation images obtained by use of 81m-krypton gas for evaluation of pulmonary dysfunction in calves.","journal":"American journal of veterinary research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"81Kr (krypton-81m) is a radioactive gas used in medical imaging. Its exact target and indications are unknown, and it is classified as a small molecule. The commercial status of 81Kr is unclear, and it may be patented or generic. Key safety considerations include its radioactive nature, which requires proper handling and disposal. Further information on its use and approval status is needed.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}