{"id":"kothala-himbutu-biscuit","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (bloating, flatulence, diarrhea)"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Kothala Himbutu is a traditional Ayurvedic plant whose active constituents (salacinol and related compounds) inhibit alpha-glucosidase and other carbohydrate-metabolizing enzymes in the small intestine, slowing glucose absorption and reducing postprandial blood glucose spikes. This mechanism may also enhance insulin secretion and improve overall glycemic control in metabolic disorders.","oneSentence":"Kothala Himbutu (Salacia reticulata) extract in biscuit form modulates postprandial glucose levels and may improve insulin sensitivity through inhibition of intestinal alpha-glucosidase enzymes.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:17:54.281Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"},{"name":"Impaired fasting glucose / prediabetes"}]},"trialDetails":[{"nctId":"NCT02290925","phase":"PHASE3","title":"The Effect of Biscuit Containing Kothala Himbutu on Blood Glucose in Patients With Diabetes. A Randomized Control Study","status":"COMPLETED","sponsor":"Rajarata University, Sri Lanka","startDate":"2014-05","conditions":"Type 2 Diabetes Mellitus","enrollment":133}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Biscuit contining Salacia reticulata extract","Kothala Himbutu Biscuit manufactured by Ceylon Biscuits Ltd","Munchee Kothala Himbutu biscuit"],"phase":"phase_3","status":"active","brandName":"Kothala Himbutu Biscuit","genericName":"Kothala Himbutu Biscuit","companyName":"Rajarata University, Sri Lanka","companyId":"rajarata-university-sri-lanka","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Kothala Himbutu (Salacia reticulata) extract in biscuit form modulates postprandial glucose levels and may improve insulin sensitivity through inhibition of intestinal alpha-glucosidase enzymes. Used for Type 2 diabetes mellitus, Impaired fasting glucose / prediabetes.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}