{"id":"korean-red-ginseng","safety":{"commonSideEffects":[{"rate":null,"effect":"Insomnia or sleep disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nervousness or anxiety"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The active constituents, particularly ginsenosides (Rb1, Rg1, Re, and others), act as adaptogens that regulate the hypothalamic-pituitary-adrenal (HPA) axis and enhance natural killer cell activity. These compounds also exhibit antioxidant and anti-inflammatory properties, improving endothelial function and glucose metabolism. The mechanism is multifactorial rather than targeting a single molecular pathway.","oneSentence":"Korean red ginseng contains ginsenosides and other bioactive compounds that modulate immune function, enhance stress resilience, and improve metabolic and cardiovascular parameters.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:19.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General immune support and stress resilience"},{"name":"Fatigue and energy enhancement"},{"name":"Cardiovascular health and endothelial function"},{"name":"Glucose metabolism and metabolic syndrome"}]},"trialDetails":[{"nctId":"NCT05592093","phase":"PHASE2, PHASE3","title":"Effect of Korean Red Ginseng on Oxidation in Middle-aged and Elderly Sub-health Population","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2023-03-01","conditions":"Healthy Ageing, Antioxidative 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Evaluate the Efficacy and Safety of EFLA400 Korea Red Ginseng Extract on Sexual Function in Men With Erectile Dysfunction","status":"COMPLETED","sponsor":"Chonbuk National University Hospital","startDate":"2010-12","conditions":"Healthy Subjects(Only Men)","enrollment":80},{"nctId":"NCT03947554","phase":"PHASE1, PHASE2","title":"Ginseng HRG80 in Stress and Fatigue","status":"COMPLETED","sponsor":"EuroPharma, Inc.","startDate":"2019-04-01","conditions":"Psychological Stress","enrollment":50},{"nctId":"NCT03865745","phase":"NA","title":"Red Ginseng Extract With Climacteric Symptoms","status":"UNKNOWN","sponsor":"MedicalExcellence","startDate":"2019-03","conditions":"Climacteric Symptoms","enrollment":53},{"nctId":"NCT01578837","phase":"PHASE1, PHASE2","title":"Combined Rg3-enriched Korean Red Ginseng and American Ginseng in the Management of Hypertension in Type 2 Diabetes","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2014-04","conditions":"Diabetes Mellitus Type 2, 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Diabetic Overweight Korean Adults","status":"COMPLETED","sponsor":"The Korean Society of Ginseng","startDate":"2010-08","conditions":"Insulin Resistance, Obesity","enrollment":80},{"nctId":"NCT00728221","phase":"PHASE2","title":"Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2007-11","conditions":"Hypertension, Blood Pressure, Endothelial Function","enrollment":17},{"nctId":"NCT00730951","phase":"PHASE2","title":"The Evaluation and Standardization of Ginseng and Its Components for Blood Pressure Regulation","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2007-06","conditions":"Hypertension","enrollment":18},{"nctId":"NCT00728403","phase":"PHASE2","title":"Metabolic and Therapeutic Effects of American and Korean Red Ginseng in the Treatment of Type 2 Diabetes","status":"UNKNOWN","sponsor":"Unity Health Toronto","startDate":"2008-09","conditions":"Diabetes Mellitus Type 2","enrollment":120},{"nctId":"NCT01542905","phase":"NA","title":"Stress Relief Effect of Korean Red Ginseng","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2010-05","conditions":"Stress Relief","enrollment":51},{"nctId":"NCT02331589","phase":"PHASE4","title":"Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis","status":"COMPLETED","sponsor":"Chuncheon Sacred Heart Hospital","startDate":"2011-08","conditions":"Fatigue","enrollment":75},{"nctId":"NCT01496248","phase":"NA","title":"Efficacy Study of Korean Red Ginseng to Treat Depression","status":"COMPLETED","sponsor":"Korea University","startDate":"2011-08","conditions":"Major Depressive Disorder","enrollment":35},{"nctId":"NCT02211352","phase":"PHASE2","title":"Effect of Korean Red Ginseng on Central Blood Pressure in Patient With Essential Hypertension","status":"COMPLETED","sponsor":"Daegu Catholic University Medical Center","startDate":"2012-05","conditions":"Hypertension","enrollment":58},{"nctId":"NCT02202382","phase":"PHASE4","title":"Effects of Korean Red Ginseng on Male Infertility","status":"COMPLETED","sponsor":"Pusan National University Hospital","startDate":"2011-04","conditions":"Male Infertility","enrollment":80},{"nctId":"NCT01951443","phase":"PHASE1","title":"Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2013-08","conditions":"Arterial Stiffness, Blood Pressure","enrollment":24},{"nctId":"NCT01699074","phase":"PHASE1","title":"Acute Dose Response of Korean White Ginseng in Metabolic Syndrome or Type 2 Diabetes","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2013-05","conditions":"Type 2 Diabetes, Metabolic Syndrome","enrollment":30},{"nctId":"NCT01664156","phase":"PHASE4","title":"Effect of Korean Red Ginseng on Women With Cold Hypersensitivity of Hands and Feet","status":"COMPLETED","sponsor":"The Korean Society of Ginseng","startDate":"2012-10","conditions":"Cold Hypersensitivity","enrollment":80},{"nctId":"NCT01911663","phase":"PHASE4","title":"The Effect of Korean Red Ginseng Supplementation on Glucose Control","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2011-11","conditions":"Diabetes","enrollment":60},{"nctId":"NCT01478009","phase":"PHASE2, PHASE3","title":"Efficacy of an Extract of Concentrated Korean Red Ginseng for Preventing Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Chonbuk National University Hospital","startDate":"2010-11","conditions":"Healthy Subjects","enrollment":100},{"nctId":"NCT00976274","phase":"NA","title":"Korean Red Ginseng and Metabolic Syndrome","status":"COMPLETED","sponsor":"The Korean Society of Ginseng","startDate":"2009-08","conditions":"Metabolic Syndrome","enrollment":60},{"nctId":"NCT00911768","phase":"PHASE4","title":"Effect of Korean Red Ginseng (KRG) on Dry Mouth","status":"COMPLETED","sponsor":"The Korean Society of Ginseng","startDate":"2007-09","conditions":"Xerostomia","enrollment":100}],"_emaApprovals":[],"_faersSignals":[{"count":5,"reaction":"DRUG RESISTANCE"},{"count":4,"reaction":"WEIGHT DECREASED"},{"count":3,"reaction":"HERPES ZOSTER"},{"count":3,"reaction":"ORAL CANDIDIASIS"},{"count":2,"reaction":"ANAEMIA"},{"count":2,"reaction":"COVID-19"},{"count":2,"reaction":"DEATH"},{"count":2,"reaction":"DIARRHOEA"},{"count":2,"reaction":"HAEMATOMA"},{"count":2,"reaction":"PRODUCT ADMINISTRATION 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Used for General immune support and stress resilience, Fatigue and energy enhancement, Cardiovascular health and endothelial function.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}