{"id":"klexane-and-asa","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Gastrointestinal bleeding"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Enoxaparin works by potentiating antithrombin III to inactivate factor Xa and thrombin, preventing thrombus formation. Aspirin irreversibly inhibits cyclooxygenase, reducing thromboxane A2 production and platelet aggregation. The combination provides both anticoagulant and antiplatelet activity for enhanced thromboprophylaxis.","oneSentence":"Klexane (enoxaparin) is a low-molecular-weight heparin that inhibits blood clotting factors, while ASA (acetylsalicylic acid) inhibits platelet aggregation, together providing dual anticoagulant and antiplatelet effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:09.008Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thromboprophylaxis in acute coronary syndrome or post-acute coronary syndrome management"},{"name":"Prevention of venous thromboembolism in high-risk patients"}]},"trialDetails":[{"nctId":"NCT00789308","phase":"PHASE2","title":"Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2008-07-11","conditions":"Diabetes Mellitus, Type I","enrollment":24},{"nctId":"NCT00959621","phase":"PHASE3","title":"Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion","status":"COMPLETED","sponsor":"University of Helsinki","startDate":"2002-01","conditions":"Habitual Abortion","enrollment":220}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Klexane and ASA","genericName":"Klexane and ASA","companyName":"University of Helsinki","companyId":"university-of-helsinki","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Klexane is a brand name for a medication that contains a low molecular weight sulfated dextran (LMW-SD). It has been studied in clinical trials for conditions such as type I diabetes and habitual abortion, often in combination with other medications like heparin, CellCept, or Rapamune.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}